Table 4.

Weight change from age 18 to baseline in relation to risk of endometrial cancer according to BMI at age 18

Weight gain (kg) between age 18 and study enrollmentBMI at age 18
Total women
<25≥25
All women*
    <5 kg1.00.70 (0.28-1.72)1.0
        Cases/person-years50/46,7396/7,55456/54,293
    5-20 kg1.18 (0.85-1.65)3.03 (1.63-5.61)1.37 (0.99-1.88)
        Cases/person-years124/99,55615/4,274139/103,830
    ≥20 kg2.24 (1.61-3.11)4.99 (2.91-8.55)2.48 (1.81-3.40)
        Cases/person-years155/65,58626/4,589181/70,175
Women never using menopausal hormone therapy
    <5 kg1.01.46 (0.39-5.53)1.0
        Cases/person-years11/21,1253/4,18614/25,311
    5-20 kg1.77 (0.91-3.41)8.00 (3.31-19.3)2.21 (1.21-4.02)
        Cases/person-years47/47,94811/2,59958/50,547
    ≥20 kg4.56 (2.42-8.60)12.3 (5.54-27.5)5.29 (2.97-9.42)
        Cases/person-years98/37,56021/3,136119/40,696
Women ever using menopausal hormone therapy
    <5 kg1.00.43 (0.12-1.55)1.0
        Cases/person-years39/25,6143/3,36842/28,982
    5-20 kg1.03 (0.70-1.52)1.13 (0.39-3.32)1.11 (0.76-1.63)
        Cases/person-years77/51,6084/1,67681/53,284
    ≥20 kg1.35 (0.89-2.06)1.77 (0.66-4.81)1.48 (0.98-2.24)
        Cases/person-years57/28,0255/1,45362/29,478
  • NOTE: Pinteraction with menopausal hormone therapy is 0.004.

  • * Adjusted for age, physical activity, personal history of diabetes, menopausal hormone therapy, age at menarche, parity, age at menopause, oral contraceptive use, smoking, race and weight at age 18.

  • Adjusted for age, physical activity, personal history of diabetes, age at menarche, parity, age at menopause, oral contraceptive use, smoking, race and weight at age 18.