Table 6.

Association between relative telomere length, cigarette smoking, and bladder cancer risk

Relative telomere lengthCases, n (%)Controls, n (%)OR (95% CI)*
NHS
Never cigarette smoker
    ≥ Median8 (42.1)9 (40.9)1.00 ref
    < Median11 (57.9)13 (59.1)0.96 (0.28, 3.36)
Ever cigarette smoker
    ≥ Median13 (31.0)25 (55.6)1.00 ref
    < Median29 (69.1)20 (44.4)3.31 (1.33, 8.27)
HPFS
Never cigarette smoker
    ≥ Median16 (41.0)18 (47.4)1.00 ref
    < Median23 (59.0)20 (52.6)1.30 (0.52, 3.21)
Ever cigarette smoker
    ≥ Median28 (33.7)45 (52.9)1.00 ref
    < Median55 (66.3)40 (47.1)2.31 (1.21, 4.41)
NHS + HPFS
Never cigarette smoker
    ≥ Median24 (41.4)27 (45.0)1.00 ref
    < Median34 (58.6)33 (55.0)1.16 (0.56, 2.41)
Ever cigarette smoker
    ≥ Median41 (32.8)70 (53.9)1.00 ref
    < Median84 (67.2)60 (46.2)2.63 (1.56, 4.45)
  • * Unconditional logistic regression adjusted for the matching factors (age, smoking status), gender, and pack-years of smoking among smokers only.