Table 2.

BMI at different ages and weight change between age 18 and study enrollment in relation to endometrial cancer risk

BMI categories (kg/m2)
Ptrend
<2525.0-29.9≥ 30
Baseline BMI
    Baseline population181/144,664296/99102<0.0001
        Cases/person-years*200/211,5381.31 (1.07-1.61)3.03 (2.50-3.68)
        Multivariate RR1.0
    With detailed RFQ information
        Cases/person-years*131/123,544111/81,706165/53,662
        Age-adjusted RR1.01.27 (0.99-1.64)2.94 (2.34-3.70)<0.0001
        Multivariate RR1.01.29 (1.00-1.66)2.88 (2.25-3.68)<0.0001
BMI at age 50
    Cases/person-years*184/160,935118/61,62892/27,884
    Age-adjusted RR1.01.72 (1.36-2.16)3.20 (2.49-4.13)<0.0001
    Multivariate RR1.01.29 (0.99-1.67)1.59 (1.09-2.32)0.172
BMI at age 35
    Cases/person-years*279/208,53467/28,70740/10,063
    Age-adjusted RR1.01.78 (1.36-2.32)3.21 (2.30-4.47)<0.0001
    Multivariate RR1.01.14 (0.85-1.53)1.35 (0.89-2.04)0.117
BMI at age 18
    Cases/person-years*329/211,88136/12,68711/3,730
    Age-adjusted RR1.01.87 (1.33-2.64)1.98 (1.09-3.62)0.003
    Multivariate RR1.01.21 (0.84-1.73)0.94 (0.50-1.76)0.400

Weight change (kg)
Ptrend
Less than −5
−5 to +4.9
5-9.9
10-19.9
≥20
Age 18 to baseline
    Cases/person-years*12/8,91044/46,39742/38,13698/67,556184/71,437
    Age-adjusted RR1.41 (0.75-2.68)1.01.16 (0.76-1.78)1.53 (1.07-2.18)2.75 (1.98-3.82)<0.0001
    Multivariate RR§1.19 (0.61-2.33)1.01.20 (0.78-1.83)1.58 (1.11-2.27)2.75 (1.96-3.86)<0.0001
  • * Total cases and person-years are different across BMI at different ages and weight change categories due to missing data on BMI at earlier ages.

  • Adjusted for age, physical activity, personal history of diabetes, menopausal hormone therapy, age at menarche, parity, age at menopause, history of oral contraceptive use, smoking, and race.

  • Adjusted for age, physical activity, personal history of diabetes, menopausal hormone therapy, age at menarche, parity, age at menopause, history of oral contraceptive use, smoking, race, and baseline BMI.

  • § Adjusted for age, physical activity, personal history of diabetes, menopausal hormone therapy, age at menarche, parity, age at menopause, history of oral contraceptive use, smoking, race, and weight at age 18.