Table 2.

Association of genotypes of chromosome 8q24 markers with prostate cancer risk

AllelesCases, n (%)Controls, n (%)OR* (95% CI)OR (95% CI)
DG8S737
    X/X494 (87.1)476 (89.0)1.00 (reference)1.00 (reference)
    −8/X67 (11.8)57 (10.7)1.13 (0.78-1.65)1.16 (0.77-1.74)
    −8/−86 (1.1)2 (0.4)2.86 (0.57-14.29)2.77 (0.49-15.68)
    −8/X or −8/−873 (12.9)59 (11.0)1.19 (0.83-1.72)1.21 (0.81-1.81)
DG8S737
    X/X534 (94.2)516 (96.4)1.00 (reference)1.00 (reference)
    −10/X or −10/−10§33 (5.8)19 (3.6)1.66 (0.93-2.96)1.68 (0.89-3.16)
SNP (rs1447295)
    CC435 (74.7)427 (79.4)1.00 (reference)1.00 (reference)
    CA136 (23.4)107 (19.9)1.24 (0.93-1.65)1.36 (0.99-1.87)
    AA11 (1.9)4 (0.7)2.65 (0.83-8.40)3.39 (0.98-11.73)
    CA or AA147 (25.3)111 (20.6)1.29 (0.97-1.70)1.43 (1.05-1.95)
DG8S737/SNP (rs1447295)
    XX/CC415 (74.1)418 (78.7)1.00 (reference)1.00 (reference)
    XX/CA or AA113 (20.2)94 (17.7)1.21 (0.89-1.64)1.36 (0.97-1.91)
    −10X or −10−10/CC2 (0.4)2 (0.4)1.28 (0.18-9.22)1.32 (0.16-11.21)
    −10X or −10−10/CA or AA30 (5.4)17 (3.2)1.74 (0.94-3.23)1.79 (0.92-3.50)
  • NOTE: Thirty cases/13 controls had missing data for DG8S737; 15 cases/10 controls had missing data for the SNP (rs1447295).

  • * Models are adjusted for age.

  • Models are adjusted for age, first-degree relative with prostate cancer, and prostate cancer screening history.

  • The X defines the group of alleles in DG8S737 other than the allele of interest.

  • § Only one individual (case) was homozygous for microsatellite allele −10. This individual was grouped with heterozygotes for all further analyses.