Table 1.

The rs1447295 variant in 8q24 and prostate cancer risk in the Australian Risk Factors for Prostate Cancer case-control study

Controls (%), N = 732Cases (%), N = 821OR* (95% CI)P
Codominant model0.002
    CC586 (80.1)595 (72.5)Reference
    CA135 (18.4)212 (25.8)1.55 (1.21-1.97)0.0005
    AA11 (1.5)14 (1.7)1.25 (0.56-2.78)0.6
PH-W > 0.9PH-W = 0.4
Dominant model0.0005
    CC586 (80.1)595 (72.5)Reference
    Any A146 (19.9)226 (27.5)1.52 (1.20-1.93)
  • * ORs and 95% CIs from unadjusted unconditional logistic regression analysis. Adjustment for family history of prostate cancer, age, country of birth, body mass index, and smoking history did not materially change the OR estimates.

  • Test for association between genotype and prostate cancer risk (likelihood ratio test).

  • Exact P value relative to the test for Hardy-Weinberg equilibrium.