Table 5.

Risk modification of dietary mutagen exposure and family history of cancer (FHxCA)

Variable*Case/con (n/n)All
Negative FHxCA
Positive FHxCA
Pinteraction
OR (95% CI)Case/conOR (n/n; 95% CI)Case/con (n/n)OR (95% CI)
MeIQx (ng/day)
    ≤55.43386/3691.0118/1611.0268/2081.0
    >55.43235/1591.48 (1.12-1.95)100/741.95 (1.28-2.97)135/851.17 (0.80-1.72)0.16
DiMeIQx (ng/day)
    ≤3.02421/3951.0119/1671.0302/2281.0
    >3.02238/1581.39 (1.05-1.83)99/682.17 (1.41-3.34)139/900.99 (0.68-1.94)0.02
PhIP (ng/day)
    ≤221.54421/3701.0139/1711.0282/1991.0
    >221.54200/1581.12 (0.85-1.48)79/641.62 (1.05-2.50)121/940.84 (0.58-1.21)0.05
BaP (ng/day)
    ≤63.56395/3711.0127/1741.0268/1971.0
    >63.56226/1571.51 (1.15-1.98)91/612.32 (1.50-3.60)135/961.16 (0.81-1.67)0.02
Mutagenicity (revertants/g/day)
    ≤8,716391/3691.0121/1691.0270/2001.0
    >8,716230/1591.41 (1.07-1.85)97/662.06 (1.35-3.16)133/931.00 (0.69-1.45)0.03
  • * The 60th percentile of the control value was used as the cutoff.

  • OR adjusted for age, race, sex, education, smoking, alcohol consumption, diabetes, and pancreatitis.