Table 4.

Sex-, age-, and country-adjusted associations between GSTP1 and GSTM3 haplotypes and risk of glioma, glioblastoma, and meningioma

Gene/haplotypeControls:*, haplotype probabilities Glioma: haplotype probabilitiesGlioma:§ OR (95% CI)Glioblastoma: haplotype probabilitiesGlioblastoma : OR (95% CI)Meningioma: haplotype probabilitiesMeningioma : OR (95% CI)
GSTM3 (GSTM3 −63/*A/*B)
H1A-*A0.420.430.95 (0.72, 1.24)0.430.97 (0.68, 1.39)0.430.97 (0.68, 1.39)
H2A-*B0.160.151.16 (0.80, 1.66)0.151.09 (0.67, 1.79)0.151.09 (0.67, 1.79)
H3C-*A0.420.410.98 (0.75, 1.28)0.420.98 (0.69, 1.40)0.420.98 (0.69, 1.40)
GSTP1(GSTP1 105/114)
H1A-C**0.650.671.12 (0.86, 1.47)0.650.96 (0.67, 1.38)0.681.20 (0.89, 1.62)
H2G-C††0.270.230.73 (0.54, 0.99)0.261.05 (0.71, 1.55)0.230.79 (0.57, 1.10)
H3G-T‡‡0.080.101.47 (0.94, 2.31)0.081.00 (0.53, 1.87)0.091.03 (0.63, 1.70)
  • NOTE: Data from population-based case-control studies conducted in Sweden, southeast England, Denmark, and Finland (2000-2004).

  • * Sample sizes differ from previous tables because subjects need data on all SNPs included in each haplotype analysis.

  • Number of controls GSTM3 = 1,552, GSTP1 = 1,481.

  • Includes haplotypes found in at least 5% of controls.

  • § Number of glioma cases GSTM3 = 680, GSTP1 = 718.

  • Number of glioblastoma cases GSTM3 = 305, GSTP1 = 327.

  • No. of meningioma cases GSTM = 523, GSTP1 = 541.

  • ** Corresponding amino acids = Ile-Ala.

  • †† Val-Ala.

  • ‡‡ Val-Val.