Table 2.

Interaction between the effect of ACC-α haplotypes and BMI on breast cancer risk

LD blockhtSNP haplotype no.htSNP haplotypeAllelic frequency in controls*Entire sample (1,564 cases/2,580 controls)
Premenopausal women (372 cases/700 controls)
Postmenopausal women (1,049 cases/1,644 controls)
OR (95% CI) BMI <25 kg/m2OR (95% CI) BMI >25 kg/m2P interOR (95% CI) BMI <25 kg/m2OR (95% CI) BMI >25 kg/m2P inter§OR (95% CI) BMI <25 kg/m2OR (95% CI) BMI >25 kg/m2P inter§
1h1-1121120.3231.05 (0.91-1.21)1.00 (0.88-1.14)0.611.13 (0.87-1.46)1.12 (0.82-1.53)0.9621.04 (0.86-1.25)0.96 (0.83-1.12)0.538
1h1-2111110.1970.98 (0.83-1.15)1.11 (0.94-1.30)0.3020.91 (0.68-1.22)1.17 (0.79-1.73)0.2991.08 (0.87-1.35)1.06 (0.87-1.28)0.868
1h1-3211210.1641.06 (0.89-1.26)0.85 (0.72-1.01)0.0830.91 (0.67-1.24)0.57 (0.37-0.89)0.0881.04 (0.83-1.31)0.96 (0.79-1.17)0.616
1h1-4112110.1211.08 (0.88-1.32)1.07 (0.88-1.30)0.9621.11 (0.78-1.59)1.09 (0.73-1.63)0.9440.99 (0.75-1.31)1.05 (0.83-1.33)0.749
1h1-5111210.0840.80 (0.62-1.03)0.97 (0.77-1.22)0.2690.79 (0.52-1.19)0.86 (0.50-1.50)0.7920.83 (0.59-1.16)1.05 (0.80-1.36)0.277
2h2-111111111110.3290.92 (0.80-1.06)1.16 (1.01-1.32)0.0220.99 (0.77-1.28)1.53 (1.13-2.07)0.0310.92 (0.76-1.10)1.09 (0.93-1.28)0.160
2h2-212111111110.1891.15 (0.97-1.37)0.90 (0.77-1.07)0.051.05 (0.77-1.43)0.69 (0.47-1.02)0.1001.23 (0.98-1.53)0.95 (0.78-1.15)0.09
2h2-321122111220.1151.08 (0.89-1.32)0.96 (0.78-1.18)0.4060.94 (0.65-1.37)0.99 (0.63-1.53)0.8801.10 (0.85-1.43)0.94 (0.74-1.20)0.393
2h2-421112111110.0850.91 (0.71-1.16)0.93 (0.74-1.16)0.9140.79 (0.50-1.23)0.75 (0.45-1.23)0.8720.88 (0.64-1.21)1.01 (0.77-1.31)0.536
2h2-511212112210.0661.10 (0.85-1.44)0.99 (0.77-1.27)0.5521.07 (0.69-1.66)1.04 (0.57-1.91)0.9481.06 (0.73-1.53)0.88 (0.66-1.18)0.457
2h2-611212111210.0610.86 (0.64-1.17)0.89 (0.69-1.15)0.8791.11 (0.67-1.83)1.09 (0.64-1.87)0.9670.82 (0.54-1.25)0.88 (0.65-1.20)0.798
2h2-721122211220.0520.85 (0.63-1.15)0.84 (0.62-1.13)0.951.03 (0.56-1.90)0.66 (0.32-1.32)0.3320.77 (0.53-1.12)0.84 (0.60-1.19)0.719
2h2-811112121110.0501.13 (0.85-1.51)1.14 (0.87-1.49)0.971.13 (0.68-1.89)1.10 (0.59-2.06)0.9511.15 (0.79-1.68)1.21 (0.88-1.67)0.847
3h3-11111110.4390.98 (0.86-1.13)1.00 (0.88-1.13)0.8880.89 (0.69-1.14)1.01 (0.76-1.33)0.5191.07 (0.90-1.28)1.02 (0.88-1.19)0.689
3h3-22121110.1630.99 (0.83-1.18)0.89 (0.75-1.06)0.4180.94 (0.67-1.31)0.85 (0.58-1.26)0.7270.96 (0.76-1.22)0.91 (0.75-1.12)0.745
3h3-32111210.1551.08 (0.90-1.30)0.91 (0.77-1.09)0.1871.08 (0.78-1.48)0.94 (0.64-1.40)0.6001.01 (0.78-1.30)0.88 (0.71-1.08)0.401
3h3-41112110.1190.96 (0.78-1.17)1.20 (0.98-1.46)0.1151.21 (0.85-1.72)1.33 (0.84-2.11)0.7430.89 (0.68-1.17)1.16 (0.92-1.45)0.150
3h3-51211110.0511.11 (0.83-1.48)1.19 (0.91-1.55)0.7251.01 (0.60-1.71)1.17 (0.63-2.16)0.7381.17 (0.81-1.70)1.27 (0.92-1.74)0.757
  • NOTE: Block 1 htSNPs: rs1714987, 32840588T>C, rs7211875, rs712039, rs2158235 (for the second SNP: position on chromosome 17, human genome assembly March 2006). Block 2 htSNPs: rs725038, rs11655013, rs2305098, rs2305097, rs11659129, rs3848462, rs9330251, rs2302803, 32731494G>T, 32770917T>C (for the last two SNPs: position on chromosome 17, human genome assembly March 2006). Block 3 htSNPs: rs1266180, rs2285655, rs3815059, rs17573357, rs2017571, rs2411161.

  • * Haplotypes observed with frequency >5% among controls.

  • P value for multiplicative interaction between the effects of ACC-α genetic variation and BMI on breast cancer risk under codominant model.