Table 1.

Association between ACC-α haplotypes and breast cancer risk by menopausal status

LD blockhtSNP haplotype nohtSNP haplotypeAllelic frequency in controls*Copies of haplotypeOR (95% CI)
P het
Entire sample (1,588 cases/2,600 controls)Premenopausal women (373 cases/700 controls)Postmenopausal women (1,072 cases/1664 controls)
1h1-1121120.323None111
One0.97 (0.84-1.11)1.08 (0.82-1.41)0.94 (0.79-1.11)
Two1.11 (0.90-1.38)1.34 (0.86-2.10)1.04 (0.80-1.35)0.321
1h1-2111110.197None111
One1.02 (0.89-1.18)1.00 (0.74-1.34)1.08 (0.90-1.29)
Two1.11 (0.79-1.55)0.98 (0.49-1.95)1.06 (0.70-1.61)0.635
1h1-3211210.164None111
One0.96 (0.83-1.11)0.65 (0.48-0.87)1.08 (0.90-1.29)
Two0.84 (0.57-1.26)1.36 (0.62-2.99)0.73 (0.45-1.21)0.016
1h1-4112110.121None111
One0.99 (0.85-1.17)1.01 (0.74-1.39)0.94 (0.77-1.15)
Two1.74 (1.03-2.94)1.58 (0.65-3.83)1.85 (0.85-4.00)0.674
1h1-5111210.084None111
One0.85 (0.71-1.03)0.88 (0.62-1.25)0.88 (0.70-1.11)
Two1.21 (0.57-2.59)0.23 (0.03-1.90)2.12 (0.84-5.31)0.642
2h2-111111111110.329None111
One1.08 (0.94-1.24)1.39 (1.05-1.83)0.98 (0.83-1.16)
Two1.00 (0.80-1.24)1.21 (0.77-1.90)1.02 (0.78-1.33)0.045
2h2-212111111110.189None111
One1.04 (0.90-1.20)0.93 (0.70-1.23)1.10 (0.92-1.31)
Two0.95 (0.66-1.37)0.66 (0.29-1.48)1.00 (0.64-1.56)0.247
2h2-321122111220.115None111
One1.06 (0.91-1.23)1.01 (0.74-1.39)1.07 (0.89-1.30)
Two0.75 (0.40-1.41)0.67 (0.20-2.19)0.57 (0.25-1.31)0.776
2h2-421112111110.085None111
One0.94 (0.79-1.13)0.75 (0.52-1.08)0.98 (0.79-1.22)
Two0.67 (0.29-1.56)0.62 (0.12-3.18)0.80 (0.29-2.22)0.204
2h2-511212112210.066None111
One1.02 (0.84-1.24)1.00 (0.69-1.46)0.94 (0.74-1.19)
Two1.46 (0.54-3.95)2.27 (0.37-13.9)1.25 (0.33-4.72)0.685
2h2-611212111210.061None111
One0.83 (0.67-1.03)0.96 (0.64-1.45)0.88 (0.68-1.15)
Two1.68 (0.65-4.36)8.52 (0.89-81.3)0.56 (0.11-2.72)0.511
2h2-721122211220.052None111
One0.86 (0.68-1.07)0.73 (0.45-1.19)0.85 (0.66-1.11)
Two0.60 (0.16-2.30)3.62 (0.33-40.4)0.21 (0.03-1.76)0.776
2h2-811112121110.050None111
One1.10 (0.89-1.36)1.07 (0.70-1.64)1.17 (0.90-1.52)
Two1.72 (0.69-4.29)2.12 (0.29-15.2)1.58 (0.52-4.77)0.771
3h3-11111110.439None111.00
One1.02 (0.88-1.18)1.07 (0.80-1.43)0.99 (0.83-1.19)
Two0.97 (0.80-1.17)0.84 (0.57-1.23)1.09 (0.87-1.37)0.924
3h3-22121110.163None111.00
One0.97 (0.85-1.12)0.97 (0.73-1.29)0.96 (0.81-1.15)
Two0.70 (0.44-1.10)0.50 (0.18-1.40)0.73 (0.42-1.27)0.946
3h3-32111210.155None111.00
One1.03 (0.89-1.20)1.02 (0.76-1.38)1.01 (0.84-1.22)
Two0.83 (0.54-1.30)1.09 (0.51-2.33)0.59 (0.32-1.08)0.758
3h3-41112110.119None111.00
One1.07 (0.91-1.25)1.21 (0.88-1.66)1.04 (0.85-1.26)
Two1.16 (0.65-2.09)2.15 (0.75-6.17)1.06 (0.51-2.20)0.321
3h3-51211110.051None111.00
One1.12 (0.91-1.39)1.02 (0.66-1.57)1.22 (0.94-1.59)
Two1.71 (0.68-4.26)2.01 (0.28-14.3)1.60 (0.53-4.84)0.516
  • NOTE: Block 1 htSNPs: rs1714987, 32840588T>C, rs7211875, rs712039, rs2158235 (for the second SNP: position on chromosome 17, human genome assembly March 2006). Block 2 htSNPs: rs725038, rs11655013, rs2305098, rs2305097, rs11659129, rs3848462, rs9330251, rs2302803, 32731494G>T, 32770917T>C (for the last two SNPs: position on chromosome 17, human genome assembly March 2006). Block 3 htSNPs: rs1266180, rs2285655, rs3815059, rs17573357, rs2017571, rs2411161.

  • * Haplotypes observed with frequency >5% among controls.

  • P value for heterogeneity of effect between subgroups of premenopausal and postmenopausal women under codominant model.