Table 3.

ORs and 95% CI for MTHFR polymorphisms with risk of endometrial cancer in the Shanghai Endometrial Cancer Study, 1997-2003

All subjects
Women never using B vitamin supplements
No. cases (%)No. controls (%)OR (95% CI)No. cases (%)No. controls (%)OR (95% CI)
Genotypes
    rs1801133 (677C>T)1,0291,016949899
        677CC356 (34.6)337 (33.2)1.0332 (35.0)301 (33.5)1.0
        677CT506 (49.2)521 (51.3)0.9 (0.8-1.1)465 (49.0)458 (50.9)0.9 (0.8-1.1)
        677TT167 (16.2)158 (15.5)1.0 (0.8-1.3)152 (16.0)140 (15.6)1.0 (0.8-1.3)
Ptrend0.800.74
    rs1801131 (1298A>C)1,0361,019954900
        1298AA699 (67.5)705 (69.2)1.0640 (67.1)619 (68.8)1.0
        1298AC300 (29.0)280 (27.5)1.1 (0.9-1.3)279 (29.2)253 (28.1)1.1 (0.9-1.3)
        1298CC37 (3.6)34 (3.3)1.1 (0.7-1.8)35 (3.7)28 (3.1)1.2 (0.7-2.0)
Ptrend0.420.38
    rs2274976 (1793G>A)1,0301,013949898
        GG856 (83.1)855 (84.4)1.0788 (83.0)756 (84.2)1.0
        AG/AA174 (16.9)158 (15.6)1.1 (0.9-1.4)161 (17.0)142 (15.8)1.1 (0.9-1.4)
Haplotypes
Cases (n = 1,029), %Controls (n = 1,013), %DominantRecessiveAdditive
    GAC41.041.41.0 (0.8-1.3)1.0 (0.7-1.4)1.0 (0.8-1.2)
    GAT40.741.00.9 (0.7-1.2)1.2 (0.8-1.7)1.0 (0.8-1.2)
    GCC9.69.31.0 (0.8-1.4)1.0 (0.2-4.0)1.0 (0.8-1.4)
    ACC8.47.81.1 (0.8-1.5)0.3 (0.1-3.2)1.0 (0.8-1.4)
  • NOTE: OR adjusted for age. Additional adjustment for education, menopausal status, diagnosis of diabetes, BMI, alcohol consumption, total energy intake, total animal food intake, and total fruit and vegetable intake did not change the results.