Table 2.

Multivariate-adjusted ORs and 95% CIs for association of dietary B vitamins with risk of endometrial cancer in the Shanghai Endometrial Cancer Study, 1997-2003

NutrientsQuartile of dietary intake*
Ptrend
Q1 (low)Q2Q3Q4 (high)
Folate (μg/d/1,000 kcal)
    Cases/controls334/303329/303278/303263/303
    OR (95% CI)1.00.8 (0.7-1.1)0.6 (0.5-0.8)0.6 (0.4-0.7)<0.01
No supplement use
    Cases/controls313/281307/268258/266232/267
    OR (95% CI)1.00.9 (0.7-1.1)0.7 (0.5-0.9)0.5 (0.4-0.7)<0.01
Riboflavin (mg/d/1,000 kcal)
    Cases/controls286/303309/303262/303347/303
    OR (95% CI)1.00.9 (0.7-1.1)0.7 (0.5-0.9)0.8 (0.6-1.1)0.10
No supplement use
    Cases/controls276/282283/287240/265311/248
    OR (95% CI)1.00.8 (0.6-1.1)0.7 (0.5-0.9)0.8 (0.6-1.2)0.22
Vitamin B6 (mg/d/1,000 kcal)
    Cases/controls251/303307/303332/303314/303
    OR (95% CI)1.01.1 (0.8-1.5)1.3 (0.9-1.8)1.0 (0.7-1.6)0.97
No supplement use
    Cases/controls238/273281/277308/269283/263
    OR (95% CI)1.01.1 (0.8-1.5)1.2 (0.8-1.8)1.0 (0.6-1.5)0.89
Vitamin B12 (μg/d/1,000 kcal)
    Cases/controls217/303279/303334/303374/303
    OR (95% CI)1.01.1 (0.8-1.5)1.1 (0.8-1.6)1.1 (0.7-1.7)0.65
No supplement use
    Cases/controls210/286261/272306/272337/252
    OR (95% CI)1.01.2 (0.8-1.6)1.2 (0.8-1.7)1.3 (0.8-2.0)0.29
Methionine (g/d/1,000 kcal)
    Cases/controls211/303274/303356/303363/303
    OR (95% CI)1.01.1 (0.8-1.5)1.2 (0.9-1.8)1.1 (0.7-1.7)0.84
  • * Quartile cut points for intake of folate, riboflavin, vitamin B6, vitamin B12, and methionine were 140.2,170.2, 205.8; 0.41, 0.51, 0.60; 0.98, 1.17, 1.40; 1.20, 1.77, 2.46; and 0.87, 1.02, 1.21, respectively.

  • Adjusted for age, education, menopausal status, diagnosis of diabetes, alcohol consumption, BMI, physical activity, total energy intake, total animal food intake, and total fruit and vegetable intake.