The genotypic (A) and allelic (B) frequencies of COMT at codons 62, 72, and 158 with pathologic grade (1 versus ≥2) in men with RCC
| (A) | ||||||
|---|---|---|---|---|---|---|
| Genotype | Grade 1 (n = 44) | Grade ≥2 (n = 77) | Total (n = 121) | |||
| Codon 62 | ||||||
| C/C | 18 (40.9%) | 32 (41.6%) | 50 (41.3%) | |||
| C/T | 20 (45.4%) | 36 (46.8%) | 56 (46.3%) | |||
| T/T | 6 (13.6%) | 9 (11.7%) | 15 (12.4%) | |||
| Codon 72 | ||||||
| G/G | 38 (86.4%) | 66 (85.7%) | 104 (86.0%) | |||
| G/T | 6 (13.6%) | 10 (13.0%) | 16 (13.2%) | |||
| T/T | 0 (0.0%) | 1 (1.3%) | 1 (0.8%) | |||
| Codon 158 | ||||||
| G/G | 23 (52.3%) | 35 (45.4%) | 58 (47.9%) | |||
| G/A | 17 (38.6%) | 36 (46.8%) | 53 (43.8%) | |||
| A/A | 4 (9.1%) | 6 (7.8%) | 10 (8.3%) | |||
| (B) | ||||||
| Allele | Grade 1 (n = 88) | Grade ≥2 (n = 154) | Total (n = 242) | |||
| Codon 62 | ||||||
| C | 56 (63.6%) | 100 (64.9%) | 156 (64.5%) | |||
| T | 32 (36.4%) | 54 (35.1%) | 86 (35.5%) | |||
| Codon 72 | ||||||
| G | 82 (93.2%) | 142 (92.2) | 224 (92.6%) | |||
| T | 6 (6.8%) | 12 (7.8%) | 18 (7.4%) | |||
| Codon 158 | ||||||
| G | 63 (71.6%) | 106 (68.8%) | 169 (69.8%) | |||
| A | 25 (28.4%) | 48 (31.2%) | 73 (30.2%) | |||
NOTE: Samples with unknown status (n = 2).