Table 5.

The genotypic (A) and allelic (B) frequencies of COMT at codons 62, 72, and 158 with pathologic grade (1 versus ≥2) in men with RCC

(A)
GenotypeGrade 1 (n = 44)Grade ≥2 (n = 77)Total (n = 121)
Codon 62
    C/C18 (40.9%)32 (41.6%)50 (41.3%)
    C/T20 (45.4%)36 (46.8%)56 (46.3%)
    T/T6 (13.6%)9 (11.7%)15 (12.4%)
Codon 72
    G/G38 (86.4%)66 (85.7%)104 (86.0%)
    G/T6 (13.6%)10 (13.0%)16 (13.2%)
    T/T0 (0.0%)1 (1.3%)1 (0.8%)
Codon 158
    G/G23 (52.3%)35 (45.4%)58 (47.9%)
    G/A17 (38.6%)36 (46.8%)53 (43.8%)
    A/A4 (9.1%)6 (7.8%)10 (8.3%)
(B)
AlleleGrade 1 (n = 88)
Grade ≥2 (n = 154)
Total (n = 242)
Codon 62
    C56 (63.6%)100 (64.9%)156 (64.5%)
    T32 (36.4%)54 (35.1%)86 (35.5%)
Codon 72
    G82 (93.2%)142 (92.2)224 (92.6%)
    T6 (6.8%)12 (7.8%)18 (7.4%)
Codon 158
    G63 (71.6%)106 (68.8%)169 (69.8%)
    A25 (28.4%)48 (31.2%)73 (30.2%)
  • NOTE: Samples with unknown status (n = 2).