Table 2.

The genotypic (A) and allelic (B) frequencies for codons 62, 72, and 158 of the COMT gene in men with and without RCC

(A)
GenotypeControls (n = 157)RCC (n = 123)Odds ratio (95% confidence intervals)
Codon 62
    C/C86 (54.8%)51 (41.5%)1.00 (reference)
    C/T63 (40.1%)57 (46.3%)1.53 (0.93-2.50)
    T/T8 (5.1%)15 (12.2%)3.16 (1.29-7.73)
P = 0.025
Codon 72
    G/G130 (82.8%)106 (86.2%)1.00 (reference)
    G/T25 (15.9%)16 (13.0%)0.78 (0.40-1.53)
    T/T2 (1.3%)1 (0.8%)0.61 (0.06-6.03)
Codon 158
    G/G85 (54.1%)59 (48.0%)1.00 (reference)
    G/A61 (38.8%)54 (43.9%)1.28 (0.78-2.09)
    A/A11 (7.0%)10 (8.1%)1.31 (0.52-3.30)
(B)
Allele
Controls (n = 314)
RCC (n = 246)
Codon 62
    C235 (74.8%)159 (64.6%)
    T79 (25.2%)87 (35.4%)
P = 0.011
Codon 72
    G285 (90.8%)228 (92.7%)
    T29 (9.2%)18 (7.3%)
Codon 158
    G231 (73.6%)172 (69.9%)
    A83 (26.4%)74 (30.1%)
  • NOTE: P values reflect χ2 test.