Table 3.

Summary of results for bladder cancer risk prediction from MDR analysis

Best modelLow riskHigh riskCross-validation consistencyAverage prediction error (%)P, permutation test
One factor
    Smoking statusNever SmokerEver smoker100/10039.42<0.001
Two factors
    Smoking statusNever Smoker and any type MUTYH Q335HEver smoker and any type MUTYH Q335H75.9/10039.42<0.001
    MUTYH Q335H
Three factors
    Smoking statusNever smokerEver smoker except for OGG1 S326C (V) and XRCC1R194W (V)85/10041.60<0.001
    XRCC1 R194W
    OGG1 S326C
Four factors
    Smoking statusNever smoker except for OGG1 S326C (W), APEX1 D148E (W), and ADPRT V762A (W)Ever smoker except for OGG1 S326C (V), APEX1 D148E (V), and ADPRT V762A (W)100/10037.02<0.001
    OGG1 S326C
    APEX1 D148E
    ADPRT V762A
Five factors
    Smoking statusNever smoker except for OGG1 S326C (W), APEX1 D148E (W), ADPRT V762A (W), and XRCC1 R194W (V)Ever smoker except for (1) OGG1 S326C (W), APEX1 D148E (V), XRCC1 R194W (W), and ADPRT V762A (V); (2) OGG1 S326C (V), APEX1 D148E (W), XRCC1 R194W (W), and ADPRT V762A (W); (3) OGG1 S326C (V), APEX1 D148E (V), XRCC1 R194W (V), and ADPRT V762A (W)100/10041.620.002
    OGG1 S326C
    APEX1 D148E
    ADPRT V762A
    XRCC1 R194W
  • NOTE: The multilocus model with maximum cross-validation consistency and maximum prediction accuracy is indicated in boldface.

    Abbreviations: W, WT genotypes; V, variant genotypes.