Table 2.

Joint effects between genotypes and smoking status in the BER pathway

GeneSmoking statusCases, nControls, nJoint effect, adjusted OR (95% CI)*Pinteraction
MUTYH Q335H
    GGNo84155Ref.
    GGYes2501852.40 (1.72-3.34)
    GC & CCNo721201.11 (0.75-1.66)
    GC & CCYes1991342.60 (1.83-3.69)0.915
OGG1 S326C
    CCNo96165Ref.
    CCYes2791832.48 (1.80-3.42)
    CG & GGNo621130.93 (0.62-1.38)
    CG & GGYes1661471.84 (1.31-2.59)0.378
APEX1 D148E
    TTNo5079Ref.
    TTYes126872.21 (1.41-3.46)
    TC & CCNo1051950.86 (0.56-1.32)
    TC & CCYes3152292.08 (1.40-3.10)0.733
XRCC1R194W
    CCNo140244Ref.
    CCYes3992802.37 (1.82-3.09)
    CT & TTNo18340.91 (0.50-1.67)
    CT & TTYes57422.28 (1.45-3.58)0.884
XRCC1R399Q
    GGNo76129Ref.
    GGYes1901382.25 (1.57-3.24)
    GA & AANo821480.96 (0.65-1.42)
    GA & AAYes2651812.39 (1.69-3.38)0.685
ADPRTV762A
    TTNo122184Ref.
    TTYes3152321.95 (1.46-2.61)
    TC & CCNo35910.58 (0.37-0.91)
    TC & CCYes134882.20 (1.53-3.14)0.019
POLD R119H
    GGNo129227Ref.
    GGYes3722682.35 (1.79-3.09)
    GA & AANo20321.08 (0.59-1.97)
    GA & AAYes57442.21 (1.41-3.49)0.710
  • * Adjusted by gender, age, and smoking status.