Table 1.

Overall main effects of genotypes on bladder cancer risk and effects stratified by smoking status

Genes (SNP ID)GenotypesControls, n (%)Cases, n (%)Adjusted OR (95% CI)*Smoking status
NeverEver
MBD4GG591 (57.2)597 (55.2)Ref.Ref.Ref.
E346K (rs140693)GA & AA5 (42.8)8 (44.8)1.74 (0.54-5.63)1.29 (0.21-7.83)2.05 (0.41-10.2)
MUTYHGG340 (57.2)334 (55.2)Ref.Ref.Ref.
Q335H (rs3219489)GC & CC254 (42.8)271 (44.8)1.08 (0.85-1.37)1.11 (0.75-1.66)1.31 (0.86-1.99)
OGG1CC348 (57.2)375 (62.2)Ref.Ref.Ref.
S326C (rs1052133)CG & GG260 (42.8)228 (37.8)0.82 (0.65-1.05)0.93 (0.62-1.39)0.74 (0.56-0.99)
APEX1TT166 (28.1)176 (29.5)Ref.Ref.Ref.
D148E (rs3136820)TC & CC424 (71.9)420 (70.5)0.91 (0.70-1.18)0.86 (0.56-1.32)0.94 (0.68-1.30)
XRCC1CC524 (87.3)539 (87.8)Ref.Ref.Ref.
R194W (rs1799782)CT & TT76 (12.7)75 (12.2)0.94 (0.66-1.34)0.91 (0.50-1.68)0.96 (0.63-1.47)
XRCC1GG267 (44.8)266 (43.4)Ref.Ref.Ref.
R399Q (rs25487)GA & AA329 (55.2)347 (56.6)1.05 (0.83-1.33)0.96 (0.65-1.43)1.06 (0.79-1.41)
POLD1GG495 (86.7)501 (86.7)Ref.Ref.Ref.
R119H (rs1726801)GA & AA76 (13.3)77 (13.3)0.97 (0.68-1.38)1.09 (0.60-1.98)0.94 (0.61-1.43)
ADPRTTT416 (69.9)437 (72.1)Ref.Ref.Ref.
V762A (rs1136410)TC & CC179 (30.1)169 (27.9)0.89 (0.68-1.15)0.58 (0.37-0.91)1.12 (0.81-1.54)
  • * Adjusted by gender, age, and smoking status.