Table 4.

Genetic polymorphisms in IL2, IFNGR2, IL2, IL10 and risk of TGCT, both overall and by subtype (seminoma and nonseminoma)

SNPGenotypeControls, n (%)Cases
Seminoma
Nonseminoma
n (%)OR* (95% CI)Pn (%)OR (95% CI)Pn (%)OR (95% CI)P
IL2TT313 (52)240 (48)1.0089 (42)1.00151 (52)1.00
IVS1−100T>GGT245 (41)214 (43)1.15 (0.90-1.48)0.2796 (46)1.37 (0.98-1.92)0.07118 (41)1.00 (0.74-1.34)0.99
GG44 (7)48 (10)1.44 (0.93-2.25)0.1126 (12)1.95 (1.13-3.36)0.0222 (8)1.04 (0.59-1.82)0.90
Ptrend0.08Ptrend0.008Ptrend0.94
IFNGR2AA (QQ)461 (76)384 (76)1.00157 (75)1.00227 (78)1.00
Ex2−16A>GAG/GG (QR/RR)143 (24)119 (24)0.99 (0.75-1.32)0.9753 (25)1.06 (0.73-1.53)0.7566 (23)0.94 (0.67-1.32)0.73
(Q64R)Ptrend0.68Ptrend0.94Ptrend0.48
IFNGR2CC182 (30)164 (32)1.0058 (28)1.00106 (36)1.00
Ex7−128C>TCT282 (47)246 (49)0.97 (0.74-1.28)0.84104 (49)1.13 (0.77-1.64)0.53142 (48)0.89 (0.65-1.23)0.49
TT143 (24)97 (19)0.76 (0.54-1.06)0.1049 (23)1.05 (0.67-1.64)0.8248 (16)0.58 (0.39-0.88)0.01
Ptrend0.13Ptrend0.79Ptrend0.01
IL10TT239 (40)180 (36)1.0079 (37)101 (35)
−3584T>AAT268 (44)245 (49)1.23 (0.95-1.60)0.12101 (48)1.09 (0.77-1.54)0.64144 (49)1.35 (0.99-1.85)0.06
AA97 (16)79 (16)1.09 (0.76-1.56)0.6331 (15)0.94 (0.58-1.53)0.8048 (16)1.20 (0.78-1.83)0.41
Ptrend0.37Ptrend0.96Ptrend0.20
IL10AA172 (29)122 (24)1.0052 (25)70 (24)
−1116A>GAG283 (47)253 (50)1.28 (0.96-1.70)0.10107 (51)1.20 (0.81-1.76)0.36146 (50)1.33 (0.94-1.88)0.11
GG148 (25)131 (26)1.26 (0.91-1.76)0.1752 (25)1.11 (0.71-1.74)0.6479 (27)1.37 (0.92-2.03)0.12
Ptrend0.16Ptrend0.63Ptrend0.12
IL10CC342 (57)302 (60)1.00120 (57)182 (62)
−853C>TCT217 (36)173 (34)0.90 (0.70-1.15)0.4078 (37)1.06 (0.76-1.48)0.7495 (32)0.79 (0.58-1.07)0.12
TT46 (8)29 (6)0.70 (0.43-1.14)0.1513 (6)0.86 (0.44-1.66)0.6516 (6)0.60 (0.33-1.10)0.10
Ptrend0.14Ptrend0.92Ptrend0.04
IL10CC341 (57)300 (59)1.00120 (57)180 (61)
−626C>AAC219 (36)176 (35)0.91 (0.70-1.17)0.4477 (37)1.03 (0.74-1.44)0.8699 (34)0.82 (0.60-1.11)0.20
AA44 (7)29 (6)0.73 (0.45-1.20)0.2213 (6)0.89 (0.46-1.72)0.7216 (5)0.63 (0.34-1.16)0.14
Ptrend0.60Ptrend0.90Ptrend0.07
Analysis by IL10 haplotype (−3584T>A, −1116A>G, −853C>T, −626C>A)
A-G-C-C38401.00381.00411.00
T-A-C-C26260.94 (0.76-1.16)0.55250.95 (0.72-1.26)0.73260.94 (0.73-1.21)0.61
T-A-T-A25230.85 (0.69-1.05)0.13240.98 (0.74-1.31)0.91220.76 (0.59-0.98)0.03
T-G-C-C10111.05 (0.78-1.40)0.77121.17 (0.80-1.71)0.43100.97 (0.68-1.39)0.88
Global P0.400.800.18
  • * Findings with P ≤ 0.05 are in boldface.

  • Data for homozygotes and heterozygotes were combined if the former consisted of fewer than five subjects.

  • Haplotypes <1% in frequency were excluded from the analysis.