Table 3.

Genetic polymorphisms in LTA/TNF and risk of TGCT, both overall and by subtype (seminoma and nonseminoma)

SNPGenotypeControls, n (%)Cases
Seminoma
Nonseminoma
n (%)OR* (95% CI)Pn (%)OR (95% CI)Pn (%)OR (95% CI)P
LTACC221 (37)171 (34)1.0082 (39)89 (30)
Ex1+49C>AAC290 (48)253 (50)1.12 (0.86-1.46)0.3999 (47)0.92 (0.65-1.30)0.65154 (52)1.29 (0.94-1.78)0.11
AA91 (15)82 (16)1.13 (0.79-1.62)0.5129 (14)0.92 (0.56-1.51)0.7553 (18)1.31 (0.85-2.01)0.22
Ptrend0.41Ptrend0.67Ptrend0.14
LTAAA273 (46)211 (42)1.0079 (38)1.00132 (45)1.00
252A>GAG261 (44)67 (13)1.13 (0.88-1.46)0.33102 (49)1.33 (0.94-1.88)0.10123 (42)1.02 (0.75-1.39)0.89
GG63 (11)292 (58)1.41 (0.95-2.08)0.0927 (13)1.39 (0.82-2.34)0.2240 (14)1.49 (0.94-2.35)0.09
Ptrend0.08Ptrend0.10Ptrend0.18
TNFCC411 (68)369 (73)1.00152 (73)217 (74)
−1042C>AAC168 (28)121 (24)0.81 (0.61-1.06)0.1250 (24)0.77 (0.53-1.12)0.1771 (24)0.82 (0.59-1.14)0.25
AA24 (4)14 (3)0.65 (0.33-1.28)0.227 (3)0.80 (0.33-1.92)0.627 (2)0.55 (0.23-1.32)0.18
Ptrend0.06Ptrend0.19Ptrend0.10
TNFCC505 (83)398 (79)1.00168 (80)230 (78)
−1036C>TCT/TT101 (17)108 (21)1.32 (0.98-1.79)0.0742 (20)1.40 (0.93-2.11)0.1166 (22)1.28 (0.90-1.83)0.17
Ptrend0.06Ptrend0.10Ptrend0.15
TNFGG420 (70)332 (66)1.00136 (65)196 (66)
−487G>AAG164 (27)1571.24 (0.95-1.61)0.1168 (32)1.18 (0.83-1.67)0.3689 (30)1.29 (0.94-1.77)0.12
AA18 (3)161.17 (0.59-2.33)0.666 (3)0.89 (0.34-2.33)0.8210 (3)1.42 (0.63-3.20)0.39
Ptrend0.14Ptrend0.56Ptrend0.10
TNFGG520 (88)4561.00185 (90)1.00271 (93)1.00
−238G>AGA69 (12)430.71 (0.47-1.06)0.0921 (10)0.85 (0.50-1.43)0.5422 (7)0.61 (0.36-1.01)0.05
Ptrend0.09Ptrend0.54Ptrend0.05
Analysis by haplotype (LTA −91C>A, LTA 252A>G, TNF −1042C>A, TNF −1036C>T, TNF −487G>A, TNF −238G>A)
A-A-C-C-G-G29281.0251.00301.00
C-G-C-C-A-G16171.16 (0.89-1.51)0.28171.23 (0.86-1.75)0.26171.13 (0.83-1.55)0.44
C-G-C-C-G-G15171.13 (0.87-1.48)0.35181.43 (1.01-2.03)0.04160.98 (0.71-1.35)0.91
C-A-A-C-G-G17140.88 (0.68-1.14)0.32150.97 (0.68-1.38)0.85140.81 (0.60-1.11)0.20
A-A-C-T-G-G8111.40 (1.01-1.93)0.04101.61 (1.03-2.50)0.04111.29 (0.88-1.89)0.20
C-A-C-C-G-G661.01 (0.69-1.48)0.9861.11 (0.66-1.87)0.6960.92 (0.58-1.45)0.71
C-A-C-C-G-A640.74 (0.48-1.14)0.1761.08 (0.62-1.87)0.7930.52 (0.30-0.92)0.02
A-G-C-C-A-G112.00 (0.77-5.20)0.16<1<1
Global P0.060.210.04
  • * Findings with P ≤ 0.05 are in boldface.

  • Data for homozygotes and heterozygotes were combined if the former consisted of fewer than five subjects.

  • Haplotypes <1% in frequency were excluded from the analysis.