Table 2.

Genetic polymorphisms in TGFB1 and risk of TGCT, both overall and by subtype (seminoma and nonseminoma)

SNPGenotypeControls, n (%)Cases
Seminoma
Nonseminoma
n (%)OR* (95% CI)Pn (%)OR (95% CI)Pn (%)OR (95% CI)P
−509C>TCC294 (49)226 (46)1.00102 (50)1.00124 (43)1.00
CT259 (43)220 (44)1.12 (0.87-1.44)0.3781 (39)0.85 (0.61-1.20)0.36139 (48)1.35 (1.00-1.82)0.05
TT48 (8)49 (10)1.35 (0.87-2.09)0.1823 (11)1.24 (0.71-2.17)0.4426 (9)1.36 (0.80-2.32)0.25
Ptrend0.15Ptrend0.95Ptrend0.06
Ex1−327T>CTT (LL)231 (38)189 (37)1.0090 (43)1.0099 (33)1.00
(L10P)CT (LP)285 (47)241 (48)1.04 (0.81-1.35)0.7591 (43)0.79 (0.56-1.11)0.17150 (51)1.27 (0.93-1.74)0.13
CC (PP)87 (14)76 (15)1.09 (0.76-1.57)0.6429 (14)0.77 (0.47-1.26)0.2947 (16)1.35 (0.87-2.09)0.18
Ptrend0.62Ptrend0.18Ptrend0.11
Ex1−282G>CGG (RR)503 (84)433 (86)1.00185 (89)1.00248 (85)1.00
(P25R)CG/CC (RP/PP)96 (16)68 (14)0.83 (0.59-1.16)0.2723 (11)0.65 (0.40-1.07)0.0945 (15)0.95 (0.64-1.40)0.79
Ptrend0.13Ptrend0.08Ptrend0.47
Ex5−73C>TCC (TT)580 (96)470 (93)1.00193 (92)1.00277 (94)1.00
(T263I)CT/TT (TI/II)24 (4)34 (7)1.73 (1.01-2.95)0.0516 (8)2.09 (1.07-4.05)0.0318 (6)1.53 (0.81-2.90)0.19
Ptrend0.05Ptrend0.03Ptrend0.19
Analysis by haplotype (−509C>T, Ex1−327T>C, Ex1−282G>C, and Ex5−73C>T)
C-T-G-C61611.0631.00591.00
T-C-G-C27281.09 (0.90-1.33)0.37260.88 (0.67-1.14)0.32301.25 (0.99-1.58)0.06
C-C-C-C970.79 (0.57-1.08)0.1460.63 (0.40-0.99)0.0580.90 (0.63-1.31)0.61
T-C-G-T231.71 (0.99-2.96)0.0641.84 (0.92-3.65)0.0831.66 (0.87-3.16)0.12
Global test0.070.040.11
  • * Findings with P ≤ 0.05 are in boldface.

  • Data for homozygotes and heterozygotes were combined if the former consisted of fewer than five subjects.

  • Haplotypes <1% in frequency were excluded from the analysis.