Table 3.

RR and 95% CI values for the association between recent weight change (1982-1992) and prostate cancer incidence (CPS-II Nutrition Cohort, 1992-2003)

Recent weight change from 1982-1992 (pounds)
Weight loss
Loss or gain
Weight gain
−21+−11 to −20−6 to −10−5 to 56-1011-2021+
All cases
    No. of cases*1133495412,450751687322
    Person-years12,62436,33047,110211,79068,51565,49535,227
    RR (95% CI)0.76 (0.63-0.92)0.81 (0.72-0.90)0.97 (0.89-1.07)1.00 (ref)0.97 (0.89-1.05)0.95 (0.87-1.03)0.85 (0.75-0.95)
    RR (95% CI)0.83 (0.69-1.01)0.84 (0.75-0.94)0.98 (0.89-1.08)1.00 (ref)0.98 (0.90-1.06)0.96 (0.88-1.05)0.88 (0.79-0.99)
    RR (95% CI)§0.84 (0.69-1.02)0.84 (0.75-0.95)0.98 (0.89-1.08)1.00 (ref)0.98 (0.90-1.06)0.97 (0.89-1.05)0.89 (0.79-1.00)
Nonmetastatic low grade
    No. of cases*832844271,908606545251
    Person-years12,62436,33047,110211,79068,51565,49535,227
    RR (95% CI)0.73 (0.58-0.91)0.86 (0.76-0.97)1.00 (0.90-1.11)1.00 (ref)1.00 (0.91-1.09)0.95 (0.86-1.05)0.83 (0.73-0.95)
    RR (95% CI)0.81 (0.65-1.01)0.90 (0.79-1.02)1.01 (0.91-1.12)1.00 (ref)1.01 (0.92-1.10)0.97 (0.88-1.07)0.88 (0.77-1.00)
    RR (95% CI)§0.85 (0.68-1.06)0.91 (0.81-1.04)1.01 (0.91-1.13)1.00 (ref)1.01 (0.92-1.11)0.98 (0.89-1.08)0.89 (0.78-1.02)
Nonmetastatic high grade
    No. of cases*456633287129
    Person-years48,95447,110211,79068,515100,722
    RR (95% CI)0.56 (0.41-0.77)0.86 (0.66-1.12)1.00 (ref)0.84 (0.66-1.07)0.88 (0.72-1.08)**
    RR (95% CI)0.58 (0.42-0.79)0.86 (0.66-1.12)1.00 (ref)0.85 (0.67-1.07)0.90 (0.73-1.11)**
    RR (95% CI)§0.55 (0.40-0.75)0.85 (0.65-1.10)1.00 (ref)0.84 (0.67-1.07)0.88 (0.71-1.08)**
Stage D or fatal cases
    No. of cases*31281373357
    Person-years48,95447,110211,79068,515100,722
    RR (95% CI)0.85 (0.58-1.26)0.82 (0.55-1.24)1.00 (ref)0.81 (0.55-1.18)1.02 (0.75-1.39)**
    RR (95% CI)0.87 (0.59-1.30)0.84 (0.56-1.26)1.00 (ref)0.80 (0.55-1.17)0.99 (0.72-1.35)**
    RR (95% CI)§0.83 (0.56-1.24)0.83 (0.55-1.24)1.00 (ref)0.80 (0.54-1.17)0.97 (0.71-1.33)**
  • * Case numbers may not sum to total 5,252 due to exclusions of extreme values of weight in 1982 and missing data.

  • Adjusted for age at interview.

  • Adjusted for age at interview, race, education, family history of prostate cancer, total calorie intake, smoking status, history of PSA testing, history of diabetes, height, and physical activity.

  • § Adjusted for age at interview, race, education, family history of prostate cancer, total calorie intake, smoking status, history of PSA testing, history of diabetes, height, physical activity, and BMI in 1982.

  • One hundred and sixty-four nonmetastatic low-grade cases excluded due to missing Gleason score information.

  • This value is for the weight loss of −11 to −20 and −21+ groups combined.

  • ** This value is for the weight gain of 11 to 20 and 21+ groups combined.