Table 3.

Adjusted mean (95% CI) percent and absolute mammographic densities by quartiles of IGF-I and IGFBP-3 concentrations and IGF-I/IGFBP-3 molar ratio by postmenopausal hormone therapy use among 977 Norwegian women

Adjusted mean* (95% CI) percent mammographic density (%)
Adjusted mean* (95% CI) absolute mammographic density (cm2)
Current hormone therapy useNoncurrent hormone therapy useNever hormone therapy useNoncurrent hormone therapy useNever hormone therapy use
IGF-In = 254n = 723n = 553n = 723n = 553
    Q110.80 (8.84-13.20)6.17 (5.24-7.27)5.98 (5.00-7.15)11.71 (9.13-15.01)8.36 (6.83-10.22)
    Q211.96 (9.34-15.31)6.65 (5.76-7.69)6.18 (5.23-7.30)12.71 (9.95-16.25)8.80 (7.29-10.63)
    Q313.17 (10.07-17.23)7.27 (6.31-8.38)7.35 (6.35-8.64)14.37 (11.32-18.25)10.26 (8.55-12.31)
    Q411.97 (8.91-16.08)7.74 (6.73-8.89)7.53 (6.34-8.95)14.97 (11.80-18.98)10.77 (8.87-13.09)
    Ptrend0.380.030.030.030.04
IGFBP-3n = 254n = 721n = 551n = 721n = 551
    Q111.13 (9.05-13.69)7.26 (6.20-8.51)7.23 (6.06-8.64)14.15 (11.07-18.09)10.41 (8.52-12.71)
    Q210.59 (8.38-13.37)6.77 (5.83-7.87)6.65 (5.59-7.91)13.04 (10.18-16.70)9.34 (7.68-11.36)
    Q313.76 (10.25-18.46)7.02 (6.10-8.06)6.53 (5.57-7.66)13.01 (10.21-16.58)9.25 (7.73-11.07)
    Q412.94 (9.88-16.94)7.02 (6.08-8.12)6.72 (5.62-8.02)13.52 (10.65-17.17)9.32 (7.63-11.39)
    Ptrend0.230.880.550.750.46
IGF-I/IGFBP-3 molar ration = 254n = 721n = 551n = 721n = 551
    Q19.94 (7.95-12.44)6.25 (5.36-7.28)6.14 (5.17-7.30)12.09 (9.45-15.47)8.70 (7.16-10.57)
    Q213.05 (10.05-16.94)6.58 (5.70-7.59)6.20 (5.25-7.33)12.62 (9.93-16.03)8.59 (7.13-10.36)
    Q313.42 (10.57-17.05)7.73 (6.67-8.96)7.49 (6.34-8.85)14.44 (11.31-18.44)10.61 (8.79-12.80)
    Q411.37 (8.78-14.72)7.54 (6.53-8.70)7.37 (6.17-8.80)14.89 (11.71-18.92)10.56 (8.65-12.90)
    Ptrend0.340.030.060.050.07
  • NOTE: Analyses are adjusted for age at screening, number of children, age at menopause, and BMI. IGFBP-3 concentration and IGF-I/IGFBP-3 ratio are missing for two women.

  • * Reported means are back-transformed from log-transformed estimated means.