Table 1.

Selected variables in relationship with mean plasma concentrations (SD) of IGF-I and IGFBP-3 and IGF-I/IGFBP3 molar ratio among postmenopausal Norwegian women (N = 977)

nIGF-I (ng/mL)PtrendnIGFBP-3 (ng/mL)PtrendnIGF-I/IGFBP-3 molar ratioPtrend
Age (y)
    <60403226.7 (72.8)4034,340 (1,011)4030.20 (0.05)
    60-64311224.3 (81.0)3104,349 (996)3100.19 (0.06)
    65-71263217.1 (67.8)0.122624,324 (964)0.862620.19 (0.05)0.11
No. children
    071221.5 (74.7)714,277 (870)710.19 (0.06)
    1-2389223.7 (68.6)3884,372 (1,024)3880.19 (0.05)
    3309221.5 (83.0)3094,251 (969)3090.20 (0.06)
    ≥4208226.1 (71.0)0.732074,428 (1,004)0.572070.19 (0.05)0.99
BMI (kg/m2), tertiles
    <25323216.8 (69.7)3234,141 (953)3230.20 (0.06)
    25-28328235.1 (82.0)3264,384 (996)3260.20 (0.06)
    ≥29326218.1 (69.1)0.833264,489 (999)<0.0013260.18 (0.05)<0.002
Age at menopause* (y)
    <48308217.0 (68.0)3074,311 (971)3070.19 (0.05)
    48-50317214.3 (67.7)3164,306 (958)3160.19 (0.05)
    >50327238.5 (82.7)<0.0013274,400 (1,043)0.243270.20 (0.06)<0.001
Postmenopausal hormone therapy use
    Never553224.5 (69.1)5514,400 (958)5510.19 (0.05)
    Past170251.8 (84.5)1704,583 (892)1700.21 (0.06)
    Current254201.9 (71.4)<0.0032544,043 (1,064)<0.0012540.19 (0.06)0.87
Smoking
    Nonsmokers645223.7 (74.9)6444,408 (988)6440.19 (0.06)
    Sometimes62223.8 (60.3)614,269 (870)610.20 (0.04)
    Daily smokers270222.3 (75.9)0.802704,188 (1,015)<0.0022700.20 (0.06)<0.05
Alcohol consumption
    Teetotaler123236.5 (70.2)1234,664 (927)1230.19 (0.05)
    No consumption reported in the previous 12 mo101223.2 (78.8)1014,410 (1,009)1010.19 (0.05)
    <1.50 g/d215224.4 (86.1)2134,264 (960)2130.20 (0.07)
    1.50-3.79 g/d219220.1 (68.5)2194,285 (965)2190.19 (0.05)
    ≥3.80 g/d224216.7 (63.3)<0.032244,233 (1,022)<0.0012240.19 (0.05)0.58
  • NOTE: IGFBP-3 concentration and IGF-I/IGFBP-3 molar ratio are missing for two women.

  • * Age at menopause is missing for 25 women.

  • Alcohol consumption is missing for 95 women.