Table 1.

Reproductive events and likelihood of anti-MUC1 antibodies

All
<45 y
46-60 y
>60 y
MUC1 antibodies
Adjusted* OR (95% CI)P trend*Adjusted* OR (95% CI)P trend*Adjusted* OR (95% CI)P trend*Adjusted* OR (95% CI)P trend*
Negative, n (%)Positive, n (%)
No. liveborn
    083 (67)40 (33)1.000.191.000.711.000.031.000.87
    161 (64)34 (36)1.24 (0.70-2.20)1.12 (0.48-2.62)3.23 (1.09-9.52)0.31 (0.07-1.51)
    2150 (68)72 (32)1.09 (0.67-1.77)0.80 (0.38-1.70)3.07 (1.19-7.91)0.35 (0.10-1.24)
    ≥3173 (65)92 (35)1.41 (0.86-2.31)0.92 (0.39-2.14)3.69 (1.39-9.79)0.61 (0.22-1.67)
    Any384 (66)198 (34)1.22 (0.79-1.89)0.91 (0.47-1.76)3.30 (1.33-8.16)0.53 (0.20-1.43)
Age at first birth (among parous women), y
    ≤2163 (57)48 (43)1.81 (1.08-3.05)0.043.15 (1.11-8.94)0.041.00 (0.47-2.11)0.944.77 (1.18-19.36)0.05
    22-25118 (68)55 (32)1.16 (0.71-1.89)1.59 (0.61-4.18)0.83 (0.41-1.68)2.20 (0.58-8.33)
    26-2996 (68)45 (32)1.09 (0.66-1.81)1.02 (0.43-2.42)0.78 (0.36-1.70)2.76 (0.69-11.03)
    >29107 (68)50 (32)1.001.001.001.00
Age at last birth (among parous women), y
    ≤2545 (56)35 (44)1.000.171.000.071.000.721.000.75
    26-30123 (68)58 (32)0.61 (0.35-1.05)0.68 (0.21-2.17)0.56 (0.26-1.20)0.57 (0.18-1.80)
    31-35130 (66)67 (34)0.67 (0.39-1.14)0.52 (0.17-1.66)0.97 (0.45-2.07)0.51 (0.17-1.55)
    >3586 (69)38 (31)0.59 (0.33-1.07)0.32 (0.09-1.21)0.67 (0.29-1.56)0.70 (0.22-2.24)
Lifetime duration of breast-feeding (among parous women), mo
    0156 (65)83 (35)1.000.581.000.371.000.741.000.09
    ≤251 (65)27 (35)0.93 (0.54-1.61)0.61 (0.21-1.74)1.16 (0.46-2.95)0.96 (0.39-2.37)
    3-1183 (68)39 (32)0.82 (0.51-1.31)0.38 (0.13-1.08)1.06 (0.54-2.06)0.85 (0.32-2.27)
    ≥1294 (66)49 (34)0.87 (0.55-1.37)1.06 (0.46-2.46)0.92 (0.46-1.83)0.37 (0.12-1.17)
    Any228 (66)115 (34)0.86 (0.60-1.24)0.72 (0.34-1.53)1.01 (0.59-1.75)0.71 (0.37-1.37)
Menstrual cycle pattern
    Regular435 (66)224 (34)1.00NA1.001.00NA1.00
    Irregular32 (70)14 (30)0.84 (0.44-1.62)0.60 (0.19-1.90)0.65 (0.17-2.40)1.22 (0.43-3.48)
Menstrual cycle length (among women with a regular pattern), d
    ≤2748 (64)27 (36)1.23 (0.73-2.07)0.321.00 (0.43-2.34)0.501.59 (0.67-3.80)0.821.08 (0.37-3.14)0.31
    28251 (69)112 (31)1.001.001.001.00
    2936 (62)20 (38)1.33 (0.73-2.42)2.49 (0.80-7.80)1.48 (0.58-3.81)0.63 (0.19-2.08)
    ≥30100 (61)65 (39)1.49 (1.01-2.19)1.23 (0.61-2.48)1.45 (0.80-2.62)1.96 (0.92-4.21)
Age at menarche, y
    ≤1186 (65)46 (35)1.18 (0.74-1.89)0.621.28 (0.57-2.85)0.341.41 (0.67-2.99)0.520.72 (0.28-1.86)0.51
    12134 (64)75 (36)1.22 (0.80-1.84)1.61 (0.80-3.23)1.18 (0.61-2.29)0.87 (0.37-2.02)
    13137 (69)63 (31)1.001.001.001.00
    ≥14110 (67)54 (33)1.13 (0.72-1.76)1.02 (0.44-2.36)1.93 (0.95-3.93)0.56 (0.24-1.28)
Age at menopause (among postmenopausal women), y
    ≤4765 (67)32 (33)1.19 (0.65-2.16)0.59NA1.22 (0.49-305)0.770.97 (0.41-2.34)0.92
    48-4942 (70)18 (30)1.05 (0.52-2.11)1.06 (0.36-3.14)1.31 (0.50-3.43)
    50-5189 (70)39 (30)1.07 (0.61-1.88)1.73 (0.74-4.06)0.80 (0.37-1.69)
    ≥5278 (71)32 (29)1.001.001.00
Oral contraceptive use, mo
    ≤3174 (71)70 (29)1.000.231.000.851.000.081.000.59
    3-1876 (66)40 (34)1.22 (0.76-1.98)2.51 (0.97-6.50)1.17 (0.53-2.56)0.77 (0.30-1.98)
    19-4886 (66)45 (34)1.16 (0.72-1.86)1.59 (0.67-3.77)0.98 (0.45-2.11)1.90 (0.63-5.77)
    49-9059 (60)40 (40)1.49 (0.89-2.48)1.74 (0.70-4.31)1.30 (0.57-2.93)4.23 (1.16-15.49)
    >9072 (63)43 (37)1.33 (0.82-2.17)1.31 (0.55-3.12)2.02 (0.90-4.52)0.81 (0.27-2.42)
    Any293 (64)168 (36)1.28 (0.90-1.83)1.42 (0.68-2.93)1.28 (0.70-2.35)1.25 (0.67-2.36)
Progestin shots, implants, or pills
    Never425 (66)221 (34)1.00NA1.001.00NA1.00NA
    Ever42 (72)17 (28)0.81 (0.45-1.47)0.60 (0.17-2.08)0.81 (0.32-2.02)0.99 (0.34-2.84)
  • Abbreviation: NA, not available.

  • * Adjusted for age (continuous) and study center (Massachusetts or New Hampshire).

  • Does not include progestin-only formulations.