Table 4.

ORs of ovarian cancer (95% confidence intervals) by tertiles of sex steroids and SHBG in postmenopausal women and their matched controls

Tertiles
Ptrend*Ptrend
123
T<1.01 nmol/L1.01-1.45 nmol/L≥1.46 nmol/L
    Cases/controls41/6751/6833/68
    Crude1.001.15 (0.67-1.98)0.71 (0.37-1.36)0.340.33
    Adjusted§1.001.13 (0.65-1.94)0.68 (0.35-1.31)0.290.25
    Adjusted1.001.12 (0.65-1.93)0.69 (0.36-1.34)0.310.23
fT<14.3 pmol/L14.3-23.6 pmol/L≥23.7 pmol/L
    Cases/controls54/6132/6132/64
    Crude1.000.63 (0.37-1.08)0.54 (0.29-0.98)0.030.19
    Adjusted§1.000.59 (0.34-1.02)0.45 (0.23-0.85)0.010.08
    Adjusted1.000.60 (0.35-1.04)0.45 (0.24-0.86)0.010.07
Δ4<2.74 nmol/L2.74-3.85 nmol/L≥3.86 nmol/L
    Cases/controls46/7347/7335/76
    Crude1.000.99 (0.60-1.65)0.65 (0.37-1.14)0.150.14
    Adjusted§1.001.00 (0.60-1.66)0.66 (0.38-1.18)0.180.15
    Adjusted1.001.06 (0.63-1.79)0.67 (0.38-1.20)0.200.19
DHEAS<1.52 μmol/L1.52-2.58 μmol/L≥2.59 μmol/L
    Cases/controls51/7740/7643/79
    Crude1.000.80 (0.47-1.37)0.81 (0.47-1.37)0.420.65
    Adjusted§1.000.81 (0.47-1.39)0.82 (0.48-1.40)0.460.71
    Adjusted1.000.82 (0.48-1.40)0.83 (0.49-1.41)0.480.74
SHBG<36.3 nmol/L36.3-52.0 nmol/L≥52.1 nmol/L
    Cases/controls50/7035/7244/73
    Crude1.000.70 (0.41-1.18)0.84 (0.49-1.44)0.490.94
    Adjusted§1.000.72 (0.41-1.25)0.89 (0.48-1.62)0.670.65
    Adjusted1.000.73 (0.42-1.27)0.89 (0.49-1.63)0.690.63
  • * Linear trends in ORs over the tertiles by scoring the categories according to the quantitative score 1, 2, and 3 for tertile categories.

  • Linear trend on continuous (log transformed) variable.

  • Analysis matched on EPIC recruitment center, age at blood donation, time of the day at blood donation, and fasting status.

  • § Further adjustment for BMI.

  • Further adjustment for ever having had a full-term pregnancy.