Table 4.

Effect of risk variants on lung cancer risk by histology using hierarchal modeling*

Squamous cell carcinoma
Adenocarcinoma
Small-cell carcinoma
CasesOR (95% CI)CasesOR (95% CI)CasesOR (95% CI)
APEX 148E, 51H4830.97 (0.79-1.19)2751.05 (0.82-1.33)1681.03 (0.77-1.39)
LIG3 250T5231.17 (0.94-1.45)2741.01 (0.80-1.29)1831.14 (0.86-1.51)
OGG1 326C/326C271.20 (0.80-1.79)241.54 (1.03-2.30)131.41 (0.87-2.28)
PARP 762A2061.01 (0.83-1.23)1191.04 (0.83-1.31)720.99 (0.76-1.29)
XRCC1 194R, 280H, 399Q6630.94 (0.52-1.68)3811.11 (0.68-1.82)2341.00 (0.52-1.92)
LIG1 7T- int9G631.15 (0.92-1.44)381.08 (0.84-1.41)231.07 (0.80-1.45)
ERCC1 8092A, 354C71.25 (0.77-2.03)11.04 (0.65-1.68)10.89 (0.26-3.06)
XPA 23A3871.00 (0.83-1.20)2441.15 (0.92-1.43)1400.99 (0.78-1.25)
XPC 939Q4381.08 (0.89-1.30)2440.92 (0.74-1.15)1560.99 (0.78-1.27)
XPD 312N4280.97 (0.78-1.22)2481.01 (0.78-1.30)1601.13 (0.84-1.52)
XPD 751Q4300.98 (0.78-1.23)2491.01 (0.79-1.30)1540.95 (0.72-1.25)
XPF 379S, 415Q810.93 (0.71-1.22)591.08 (0.81-1.45)271.02 (0.70-1.48)
XPG 1104H6351.10 (0.78-1.54)3640.94 (0.65-1.35)2190.86 (0.60-1.24)
MGMT 171T, 84F1860.93 (0.75-1.14)1191.09 (0.86-1.38)630.93 (0.70-1.23)
MGMT 143V, 178R1511.17 (0.94-1.46)981.25 (0.98-1.61)601.19 (0.88-1.61)
MLH1 219V3581.11 (0.92-1.34)1880.96 (0.77-1.20)1150.97 (0.75-1.26)
XRCC2 188H631.03 (0.77-1.38)441.07 (0.78-1.46)401.61 (1.15-2.24)
XRCC3 241T5951.21 (0.92-1.59)3361.02 (0.75-1.38)2181.59 (1.10-2.28)
XRCC4 298N1461.09 (0.87-1.36)760.91 (0.70-1.19)551.28 (0.94-1.75)
CHEK2 157I6572.00 (1.16-3.47)3671.06 (0.71-1.59)2291.56 (0.98-2.47)
CCND1 870A4871.10 (0.90-1.35)2801.05 (0.83-1.32)1711.03 (0.80-1.32)
MDM2 162G770.96 (0.74-1.26)430.93 (0.69-1.26)270.96 (0.70-1.32)
MDM2 309G3951.02 (0.85-1.23)2341.01 (0.81-1.25)1270.88 (0.69-1.14)
MMP1 insG4831.09 (0.90-1.33)2761.02 (0.81-1.29)1650.97 (0.76-1.25)
CDKN2A 148T320.99 (0.69-1.41)231.03 (0.71-1.49)201.26 (0.86-1.84)
CDKN1A 31R1061.16 (0.91-1.47)510.99 (0.75-1.32)381.11 (0.83-1.48)
TP53 Int3A2 -72P221.48 (0.92-2.38)81.16 (0.75-1.80)41.19 (0.72-1.96)
P73 14T1821.17 (0.96-1.43)1030.96 (0.76-1.22)691.10 (0.85-1.42)
Estimated τ20.0416Set to 0.050.0217
Pathway estimation
    BER1.07 (0.85-1.34)1.07 (0.83-1.39)1.05 (0.84-1.33)
    NER1.04 (0.86-1.25)0.98 (0.79-1.21)0.96 (0.80-1.15)
    MMR/DR1.06 (0.79-1.43)1.04 (0.74-1.45)0.95 (0.71-1.28)
    DSB1.22 (0.79-1.88)0.88 (0.55-1.42)1.26 (0.81-1.97)
    Cell cycle1.15 (0.96-1.37)1.00 (0.82-1.22)1.02 (0.85-1.22)
    SIFT1.00 (0.67-1.48)1.17 (0.76-1.81)1.21 (0.80-1.82)
  • * Prior matrix included pathway indicators and a SIFT covariate.