Table 5.

Risk of colorectal adenomas associated with postmenopausal hormone use, stratified by LEPR genotype, among postmenopausal women

Postmenopausal hormone use
Never
Ever
Cases/controlsOR (95% CI)*Cases/controlsOR (95% CI)*
LEPR
Lys109Arg
    AA11/161.029/261.7 (0.7-4.3)
    AG/GG10/62.1 (0.6-7.6)13/290.6 (0.2-1.5)
    P interaction0.01
Gln223Arg
    AA4/111.017/123.3 (0.9-11.4)
    AG/GG17/112.3 (0.7-8.1)25/430.9 (0.3-2.6)
    P interaction<0.01
Ser343Ser
    TT13/141.027/350.8 (0.3-1.9)
    TC/CC8/80.7 (0.2-2.4)15/200.6 (0.2-1.8)
    P interaction0.99
Lys656Asn
    GG17/131.028/440.5 (0.2-1.1)
    GC/CC4/90.3 (0.1-1.2)14/111.1 (0.4-3.2)
    P interaction0.03
Pro1019Pro
    CC11/91.018/220.7 (0.2-2.0)
    CT/TT10/130.5 (0.2-1.8)24/330.6 (0.2-1.5)
    P interaction0.79
  • * Adjusted for age, BMI, family history of colorectal cancer, NSAID use, cigarette smoking, and physical activity.