Table 4.

Risk of colorectal adenomas associated with LEPR genotypes and haplotypes

Cases (n = 157), %Controls (n = 191), %OR (95% CI)*
LEPR single polymorphisms
Lys109Arg
    AA58541.0
    AG/GG42470.8 (0.5-1.2)
Gln223Arg
    AA32331.0
    AG/GG69671.0 (0.6-1.6)
Ser343Ser
    TT62671.0
    TC/CC38341.1 (0.7-1.7)
Lys656Asn
    GG69681.0
    GC/CC31321.0 (0.6-1.6)
Pro1019Pro
    CC42361.0
    CT/TT58640.8 (0.5-1.2)
LEPR haplotypes
    AATGC37351.0
    GGTGT17200.8 (0.5-1.2)
    AATCT16160.9 (0.6-1.5)
    AGCGC16151.0 (0.6-1.6)
    GGTGC661.1 (0.6-2.0)
  • * Adjusted for age and sex.

  • In order of 109, 223, 343, 656, and 1019.