Table 3.

Risk of colorectal adenomas associated with body mass index (BMI)

Cases (n = 157), n (%)OR* (95% CI)OR (95% CI)
Men
    BMI, kg/m2 (quartiles)
        <24.813 (17)1.01.0
        24.8-26.58 (11)0.5 (0.2-1.6)0.4 (0.1-1.3)
        26.6-29.126 (34)1.9 (0.7-5.3)1.3 (0.4-4.1)
        >29.129 (38)2.4 (0.9-6.5)1.5 (0.4-5.3)
        P trend (continuous per kg/m2)0.020.30
    BMI
        <25.016 (21)1.01.0
        25.0-29.935 (46)1.0 (0.4-2.4)0.5 (0.2-1.6)
        ≥30.025 (33)2.6 (0.9-7.4)1.2 (0.3-4.6)
Women
    BMI, kg/m2 (quartiles)
        <23.220 (25)1.01.0
        23.2-26.627 (34)1.3 (0.6-3.0)1.0 (0.4-2.6)
        26.7-30.113 (16)0.8 (0.3-2.1)0.6 (0.2-1.9)
        >30.120 (25)1.1 (0.4-2.5)0.8 (0.2-2.8)
        P trend (continuous per kg/m2)0.560.56
    BMI
        <25.032 (40)1.01.0
        25.0-29.928 (35)1.2 (0.6-2.4)1.1 (0.5-2.5)
        ≥30.020 (25)1.0 (0.5-2.1)1.0 (0.3-2.8)
  • * Adjusted for age, family history of colorectal cancer, NSAID use, cigarette smoking, and physical activity; additional adjustments for menopausal status and postmenopausal hormone use in women.

  • Same adjustments as above but additionally adjusted for circulating leptin concentrations.

  • WHO cut points in kg/m2 (not overweight, <25; overweight, 25-29.9; obese, ≥30; ref 26).