Table 2.

Risk of colorectal adenomas associated with leptin concentrations (ng/mL)

Cases, n (%)Controls, n (%)OR* (95% CI)OR (95% CI)
Men(n = 77)(n = 72)
    1-510 (13)24 (33)1.01.0
    6-1027 (35)24 (33)2.7 (1.0-7.2)2.4 (0.9-6.8)
    11-8040 (52)24 (33)3.3 (1.2-8.7)2.3 (0.7-7.7)
    P trend (continuous per ng/mL)0.010.15
Women(n = 80)(n = 119)
    2-1623 (29)40 (34)1.01.0
    17-4332 (40)39 (33)1.3 (0.7-2.4)1.7 (0.7-4.1)
    44-15825 (31)39 (33)0.8 (0.4-1.6)1.3 (0.4-3.8)
    P trend (continuous per ng/mL)0.460.20
  • * Adjusted for age, family history of colorectal cancer, NSAID use, cigarette smoking, and physical activity; additional adjustments for menopausal status and postmenopausal hormone use in women.

  • Same adjustments as above but additionally adjusted for BMI (in sex-specific quartiles).