Table 3.

VDR SNP and 3′ area BsmI-ApaI-TaqI combined genotype associations with epithelial ovarian cancer risk

GenotypeCaucasian
Japanese
Cases n (%)Controls n (%)OR (95% CI)*Cases n (%)Controls n (%)OR (95% CI)
rs7975232 (ApaI)
    aa11 (16)33 (24)1.0 reference38 (41)75 (45)1.0 (reference)
    aA37 (53)72 (52)2.8 (1.2-7.0)47 (50)79 (47)1.2 (0.7-2.1)
    AA22 (31)34 (24)3.4 (1.3-9.1)8 (9)14 (8)1.2 (0.5-3.1)
Ptrend0.020.56
rs1544410 (BsmI)
    bb26 (27)48 (33)1.0 (reference)72 (77)137 (80)1.0 (reference)
    bB30 (42)70 (49)1.2 (0.6-2.4)19 (20)28 (16)1.4 (0.7-2.8)
    BB15 (21)26 (18)1.3 (0.5-3.3)3 (3)6 (4)0.9 (0.2-4.0)
Ptrend0.530.49
rs731236 (TaqI)
    TT26 (36)48 (33)1.0 reference73 (79)138 (80)1.0 (reference)
    Tt30 (42)77 (53)1.1 (0.5-2.1)17 (18)31 (18)1.1 (0.6-2.2)
    tt16 (22)21 (14)1.8 (0.7-4.4)3 (3)4 (2)1.7 (0.4-7.9)
Ptrend0.280.53
rs10735810 (FokI)
    FF16 (23)58 (40)1.0 reference37 (40)74 (43)1.0 (reference)
    Ff44 (62)64 (44)2.5 (1.3-4.8)48 (52)80 (47)1.2 (0.7-2.0)
    ff11 (15)22 (15)2.1 (0.8-5.2)8 (9)18 (10)0.9 (0.4-2.2)
Ptrend0.040.87
rs11568820 (Cdx-2)
    GG44 (63)95 (66)1.0 reference36 (39)45 (26)1.0 (reference)
    GA21 (30)44 (30)1.0 (0.6-1.8)41 (45)99 (58)0.5 (0.3-0.9)
    AA5 (7)6 (4)1.5 (0.4-5.2)15 (16)27 (16)0.9 (0.4-1.8)
Ptrend0.960.03
BsmI-ApaI-TaqI
    bb/aa/TT11 (16)33 (24)1.0 reference75 (45)38 (41)1.0 reference
    bb/aA/TT13 (19)12 (9)4.2 (1.3-13.1)31 (33)55 (33)1.1 (0.6-1.9)
    bB/aA/Tt24 (35)54 (40)2.3 (0.9-5.9)15 (16)19 (11)1.8 (0.8-4.0)
    bB/AA/Tt5 (7)12 (9)2.4 (0.6-9.7)2 (2)8 (5)0.5 (0.1-2.4)
    BB/AA/tt15 (22)16 (12) 5.2 (1.6-17.5)3 (3)1 (2)2.3 (0.4-12.3)
  • * For 3′ area SNPs (ApaI, BsmI, and TaqI) and combined genotypes, adjusted for education, gravidity, use of oral contraceptives, and menopausal hormones.

  • For 3′ area SNPs and combined genotypes, adjusted for education and use of menopausal hormones.