Table 4.

Dose-response association between general obesity and colorectal cancer before and after correction for publication bias (reference group is BMI <25 kg/m2; normal weight)

Cancer type/sexNo. reportsNo. eventsBMI (kg/m2)
Uncorrected for publication bias
Corrected for publication bias
25-29.9 overweight≥30 Obese25-29.9 Overweight≥30 Obese
Colon
    Male915,7451.25 (1.14-1.37)1.51 (1.42-1.61)1.23 (1.11-1.36)1.53 (1.33-1.75)
    Female918,6741.09 (0.99-1.20)1.16 (1.01-1.34)1.05 (0.95-1.16)1.09 (0.93-1.28)
    All1834,4191.18 (1.09-1.28)1.38 (1.20-1.59)1.11 (1.02-1.19)1.21 (1.06-1.38)
Rectum
    Male69,8461.08 (0.97-1.20)1.29 (1.19-1.40)1.08 (0.97-1.20)1.27 (1.17-1.37)
    Female68,3031.02 (0.88-1.17)1.08 (0.92-1.26)0.97 (0.83-1.14)1.02 (0.85-1.22)
    All1218,1491.04 (0.97-1.12)1.21 (1.05-1.39)1.03 (0.95-1.12)1.12 (0.98-1.28)
Colorectal
    Male1525,5911.19 (1.09-1.30)1.47 (1.33-1.61)1.16 (1.07-1.27)1.40 (1.33-1.47)
    Female1526,9771.05 (0.99-1.11)1.11 (1.03-1.20)1.03 (0.96-1.10)1.07 (0.97-1.18)
    All3052,5681.13 (1.06-1.19)1.31 (1.19-1.45)1.09 (1.02-1.15)1.19 (1.08-1.30)