Table 3.

Cohort studies reporting on the association between central obesity and risk of colorectal cancer

First author/year (reference number)Cohort
Outcome
Waist circumference (cm)
Level of adjustment
CountryNo. (sex)SourceCancer subtypeEventsPer 2-unit increase
Groups
RR (95% CI)ClassRR (95% CI)
Pischon, 2006 (20)EPIC (Europe)129,731 (M)MR,CR, SR,P,PRC4211.05 (1.02-1.07)<861.001,2,4,5,11,12,13,19,20
86.0-91.80.73 (0.50-1.04)
91.9-96.50.97 (0.69-1.36)
96.6-102.91.10 (0.79-1.53)
≥1031.39 (1.01-1.93)
238,546 (F)C5631.02 (0.99-1.04)<70.21.00
70.2-75.81.10 (0.80-1.52)
75.9-80.91.23 (0.90-1.68)
81.0-88.91.25 (0.91-1.70)
≥891.48 (1.08-2.03)
MR295NA<861.00
86.0-91.81.06 (0.70-1.61)
91.9-96.51.15 (0.76-1.73)
96.6-102.91.18 (0.78-1.77)
≥1031.27 (0.84-1.91)
FR291NA<70.21.00
70.2-75.81.10 (0.73-1.66)
75.9-80.90.94 (0.62-1.42)
81.0-88.91.22 (0.82-1.83)
≥891.23 (0.81-1.86)
Larsson, 2006 (16)COSM (Sweden)45,906 (M)CR, DCCR496NA<881.001,4,8,10,11,13,20
88.0-92.01.06 (0.73-1.55)
93.0-97.01.32 (0.92-1.88)
98.0-1031.37 (0.96-1.96)
≥1031.29 (0.90-1.85)
Ahmed, 2006 (21)ARIC (USA)14,109 (M+F)SR,CRCR194NALow1.001,2,4,5,8
High1.40 (1.00-1.90)
MacInnis, 2006 (18)MCCS (Australia)24,479 (F)CR,DC,MRC2121.03 (1.00-1.05)<80.01.001,8,13,17
80.0-87.01.40 (1.00-1.90)
≥88.01.40 (1.00-1.90)
MacInnis, 2006 (17)MCCS (Australia)41,528 (M+F)CR,DC,MRR2291.01 (0.95-1.08)<94/<801.001,2,17
94-102/80-87.91.20 (0.90-1.60)
≥102/≥881.40 (1.00-1.90)
MR1.04 (0.94-1.14)<941.00
94-1021.30 (0.90-1.90)
≥1021.40 (0.90-2.20)
FR0.99 (0.91-1.08)<801.00
80-87.91.00 (0.60-1.70)
≥881.40 (0.80-2.20)
Moore, 2004 (30)Framingham (USA)3,764 (M+F)NR,MR,DCC157NASmall1.001,2,4,5,11,13,20
Medium1.10 (0.66-2.00)
Large1.60 (0.91-2.90)
X-large2.00 (1.10-3.70)
M 30-45 yC71NA<83.81.00
83.8-<94.01.10 (0.49-2.30)
94.0-<101.61.60 (0.73-3.60)
≥101.62.40 (0.99-5.70)
FC72NA<81.31.00
30-45 y81.3-<91.41.20 (0.53-2.50)
91.4-<99.11.60 (0.71-3.70)
≥99.11.80 (0.78-4.30)
MC71NA<83.81.00
55-79 y83.8-<94.01.30 (0.51-3.10)
94.0-<101.62.20 (0.87-5.40)
≥101.63.30 (1.30-8.80)
FC72NA<81.31.00
55-79 y81.3-<91.41.50 (0.58-3.90)
91.4-<99.12.00 (0.75-5.30)
≥99.12.30 (0.86-6.30)
MacInnis, 2004 (28)MCCS (Australia)17,049 (M)CR, MRColon1531.06 (1.03-1.10)<87.01.001,13,17
87.0-92.90.80 (0.40-1.40)
93.0-99.31.70 (1.00-2.80)
>99.32.10 (1.30-3.50)
Schoen, 1999 (38)CHS (USA)5,849 (M+F)MR,SRColorectal102NAQuartile11.001,2,11
Quartile22.20 (1.20-4.00)
Quartile31.40 (0.70-2.70)
Quartile42.20 (1.20-4.10)
Martinez, 1997 (39)NHS (USA)89,448 (F)MR,NR,P, PR,PSColon393NA<27.5 in.1.001,4,5,8,10,11,12
>34.0 in.1.48 (0.89-2.46)
Giovannucchi, 1995 (40)
HPFS (USA)47,723 (M)SR,P,MR, PRColon203NA<35 in.1.001,4,5,8,10,11,12
35.0-36.90.56 (0.27-1.14)
37.0-38.91.09 (0.59-2.01)
39.0-42.91.61 (0.91-2.85)
≥43 in.2.56 (1.33-4.96)