Table 2.

Case-control studies reporting on the association between obesity and risk of colorectal cancer

Firstauthor/year (reference number)CountryCancer cases
Controls
BMI status (kg/m2)
Level of adjustment
SourceCancer sub typeNo.SourceNo.Obesity definition (kg/m2Per 2-unit increase
Groups
number)RRClassRR (95% CI)
Elwing, 2006 (41)USANewly diagnose patientsCR (F)159Hospital610>30NA≤30.01.001,3,6,7,8,9
>30.01.82 (1.26-2.62)
Guilera, 2005 (42)USAHospitalCR (M+F)226Hospital494>30NA<25.01001,2
25.0-30.01.00 (0.70-1.50)
>30.01.70 (1.10-2.50)
Pan, 2004 (43)CanadaNewly diagnosed patientsC (M)959Community5,039>30NA<25.01.001,4,5,10,12,14,15,16
C (F)768>30NA25.0-30.01.54 (1.27-1.86)
≥30.02.16 (1.68-2.78)
<25.01.00
25.0-30.01.22 (0.98-1.52)
≥30.01.77 (1.35-2.32)
R (M)858>30NA<25.01.00
25.0-30.01.41 (1.15-1.71)
≥30.01.75 (1.35-2.28)
R (F)589>30NA<25.01.00
25.0-30.01.28 (1.02-1.61)
≥30.01.50 (1.11-2.02)
Slattery, 2003 (44)USACRGC (M)1,095Community1,286>30NA<231.001
23-240.96 (0.64-1.44)
25-271.13 (0.79-1.63)
28-301.54 (1.06-2.23)
>301.88 (1.29-2.74)
C (F)8771,100>30NA<231.00
23-241.22 (0.90-1.65)
25-271.27 (0.96-1.67)
28-301.30 (0.96-1.76)
>301.45 (1.09-1.92)
Slattery, 2003 (45)USACRGR (M)556Community626>30NA<23.01.00
23.0-25.00.80 (0.50-1.30)
25.1-28.00.90 (0.60-1.30)
28.1-30.00.70 (0.50-1.10)
>30.01.00 (0.70-1.60)1
R (F)390525>30NA<23.01.00
23.0-25.00.90 (0.60-1.30)
25.1-28.00.80 (0.50-1.40)
28.1-30.00.80 (0.50-1.40)
>30.01.10 (0.80-1.60)
Russo, 1998 (46)ItalyPatientsCR (M)1,124Hospital2,067NANA<22.71.001,11,12,13,19
22.7-24.61.32 (1.00-1.76)
24.6-26.51.19 (0.89-1.57)
26.5-28.71.45 (1.09-1.92)
>28.71.68 (1.25-2.27)
CR (F)8192,069NANA<22.71.00
22.7-24.60.91 (0.70-1.18)
24.6-26.50.84 (0.64-1.12)
26.5-28.71.16 (0.86-1.55)
>28.70.87 (0.65-1.17)
Slattery, 1997 (47)USANewly diagnosed patientsC (M)1,099Community1,290>30NA<23.81.001,8,10,11,12
23.8-25.51.23 (0.93-1.63)
25.5-27.31.32 (1.00-1.74)
27.3-30.01.78 (1.36-2.33)
>30.01.94 (1.49-2.54)
C (F)8941,120>30NA<23.81.00
23.8-25.51.26 (0.94-1.68)
25.5-27.31.19 (0.89-1.60)
27.3-30.01.38 (1.03-1.85)
>30.01.45 (1.08-1.94)
Kune, 1990 (48)AustraliaNewly diagnosed patientsCR (M)388Community398≥31NA<19.00.47 (0.20-1.20)1,12
20.0-25.01.00
26.0-30.01.38 (1.00-2.00)
≥31.01.70 (0.80-3.60)
CR (F)327329≥31NA<18.00.39 (0.20-0.90)
19.0-24.01.00
25.0-30.00.70 (0.50-1.00)
≥31.00.71 (0.40-1.40)
C (M)202398≥311.06 (0.96-1.17)<19.00.09 (0.00-0.70)
20.0-25.01.00
26.0-30.01.18 (0.80-1.80)
≥31.01.17 (0.50-2.90)
C (F)190329≥310.96 (0.90-1.04)<18.00.41 (0.20-1.10)
19.0-24.01.00
25.0-30.00.74 (0.50-1.20)
≥31.00.73 (0.30-1.60)
R (M)186398≥31NA<19.00.93 (0.30-2.50)
20.0-25.01.00
26.0-30.01.54 (1.00-2.40)
≥31.02.09 (0.90-5.00)
R (F)137329≥31NA<18.00.32 (0.10-1.00)
19.0-24.01.00
25.0-30.00.60 (0.40-1.00)
≥31.00.61 (0.20-1.50)