Table 2.

Adjusted ORs with 95% CIs for several potential markers according to atrophic gastritis, corpus atrophic gastritis, and intestinal metaplasia in Costa Rican dyspeptic patients

FactorsAtrophic gastritis
Corpus atrophic gastritis
Intestinal metaplasia
Pos/NegOR (95% CI)Pos/NegOR (95% CI)Pos/NegOR (95% CI)
PG values
    Low levels*
        Pos45/646.0 (2.8-12.9)29/8021.5 (4.7-98.2)19/905.2 (1.6-16.1)
        Neg13/1012/1124/110
    Very low levels
        Pos30/316.3 (2.9-13.5)25/3628.3 (9.2-86.8)18/4314.0 (4.8-41.5)
        Neg28/1346/1565/157
Bacterial markers
    CagA-ab
        Pos48/803.6§ (1.4-8.8)27/1015.5§ (1.4-21.2)22/10648.6§ (4.1-569)
        Neg/HP-neg10/854/911/94
Host susceptibility markers
    IL-1β −511
        T/T16/261.9 (0.7-5.1)8/341.4 (0.4-4.8)8/343.3 (0.8-13.7)
        T/C30/881.0 (0.4-2.3)16/1020.9 (0.3-2.6)12/1061.5 (0.4-5.8)
        T carrier46/1141.2 (0.5-2.7)24/1361.0 (0.4-2.8)20/1401.9 (0.5-7.0)
        C/C11/361.0 (reference)6/411.0 (reference)3/441.0 (reference)
    IL-1β +3954
        T/T1/24.6 (0.3-62.7)0/300/30
        T/C33/771.3 (0.7-2.6)19/911.6 (0.7-3.7)18/923.5 (1.2-10.1)
        T carrier34/791.4 (0.7-2.7)19/941.5 (0.7-3.6)18/953.4 (1.2-10.0)
        C/C23/711.0 (reference)11/831.0 (reference)5/891.0 (reference)
    IL-1RN intron 2
        *2/*213/202.1 (0.8-5.2)9/242.9 (1.0-8.3)8/253.1 (1.1-9.0)
        *2/L18/491.1 (0.5-2.3)8/590.9 (0.3-2.4)5/620.7 (0.2-2.2)
        *2 carrier31/691.3 (0.7-2.3)17/831.4 (0.6-3.2)13/871.4 (0.6-3.3)
        L/L26/811.0 (reference)13/941.0 (reference)10/971.0 (reference)
    IL-10 −1082
        A/A35/811.2 (0.4-4.1)17/990.8 (0.2-3.7)12/1042.2 (0.2-18.9)
        G/A17/560.9 (0.3-3.1)10/630.9 (0.2-4.1)10/633.2 (0.4-28.3)
        A carrier52/1371.1 (0.3-3.5)27/1620.9 (0.2-3.6)22/1672.6 (0.3-21.5)
        G/G5/131.0 (reference)3/151.0 (reference)1/171.0 (reference)
    IL-10 −592
        A/A8/122.1 (0.7-6.1)4/161.9 (0.5-7.2)4/162.7 (0.7-10.4)
        C/A19/580.8 (0.4-1.7)10/670.8 (0.3-2.0)8/691.0 (0.4-2.8)
        A carrier27/701.0 (0.5-2.0)14/831.0 (0.4-2.3)12/851.3 (0.5-3.3)
        C/C30/801.0 (reference)16/941.0 (reference)11/991.0 (reference)
  • NOTE: T carrier, T/T + T/C; A carrier, A/A + G/A or C/A; L, alleles 1, 3, 4 and 5; *2 carrier, *2/*2 + *2/L. HP-neg, H. pylori negative. ORs are adjusted for sex, age, and H. pylori seropositivity.

  • * With cutoff levels PG I ≤70 μg/L + PG I/II ≤3.

  • P < 0.001, vs controls.

  • With cutoff levels PG I ≤30 μg/L + PG I/II ≤2.

  • § P < 0.01, vs controls.

  • P < 0.05, vs controls.