Table 4.

Sex-, age-, and country-adjusted associations between IL-4Rα and IL-13 haplotypes and allergies among glioblastoma controls

HaplotypeAll allergies,* (n = 744/741),
All allergies*
Asthma cases (n = 152)
Asthma
Eczema cases (n = 307)
Eczema
Hayfever cases (n = 342)
Hayfever
Haplotype frequenciesOR§ (95% CI)Haplotype frequenciesOR§ (95% CI)Haplotype frequenciesOR§ (95% CI)Haplotype frequenciesOR§ (95% CI)
IL-4Rα
    H1, T-G0.04/0.050.59 (0.30-1.17)0.040.59 (0.16-2.15)0.050.75 (0.31-1.81)0.030.38 (0.14-1.03)
    H2, C-G0.17/0.180.86 (0.58-1.26)0.181.08 (0.56-2.11)0.170.94 (0.57-1.55)0.180.94 (0.57-1.54)
    H3, T-A0.80/0.771.31 (0.92-1.86)0.781.06 (0.58-1.95)0.781.14 (0.72-1.79)0.791.31 (0.83-2.06)
IL-13
    J1, G-C0.70/0.720.71 (0.51-0.98)0.690.70 (0.40-1.23)0.670.58 (0.38-0.89)0.710.77 (0.50-1.19)
    J2, A-C0.09/0.091.08 (0.62-1.87)0.090.81 (0.32-2.05)0.101.53 (0.77-3.04)0.091.13 (0.56-2.27)
    J3, G-T0.09/0.081.42 (0.80-2.51)0.112.46 (0.97-6.23)0.091.67 (0.80-3.46)0.081.09 (0.52-2.31)
    J4, A-T0.13/0.111.51 (0.94-2.41)0.121.30 (0.57-2.93)0.131.52 (0.84-2.76)0.121.44 (0.78-2.66)
  • NOTE: Data are results from population-based case-control studies conducted in Sweden, Southeast England, Denmark, and Finland (2000-2004).

  • * Includes self-reported asthma, hayfever, eczema, food allergy, and all other allergic conditions.

  • Number of controls (n = 1,485) differs from those in Table 3 (n = 1,525) because people with missing values for allergies are excluded from Table 4 analyses.

  • Controls are people reporting no allergies.

  • § Each haplotype is included in a separate model with the reference category consisting of individuals who did not have that specific haplotype.