Table 3.

Sex- and age-adjusted country-specific and country-adjusted associations between IL-4Rα and IL-13 haplotypes and glioblastoma

HaplotypeSweden (102/390)*
Southeast England (102/435)*
Denmark (65/592)*
Finland (44/108)*
Total (313/1,525)*
Haplotype frequencies (cases/controls)OR (95% CI)Haplotype frequencies (cases/controls)OR (95% CI)Haplotype frequencies (cases/controls)OR (95% CI)Haplotype frequencies (cases/controls)OR (95% CI)Haplotype frequencies (cases/controls)OR (95% CI)
IL-4Rα
    H1, T-G0.07/0.052.12 (0.66-6.80)0.07/0.052.86 (0.81-10.11)0.08/0.052.46 (0.61-9.91)0.06/0.061.15 (0.13-10.17)0.07/0.052.26 (1.13-4.52)
    H2, C-G0.22/0.171.83 (0.86-3.89)0.22/0.171.81 (0.81-4.07)0.15/0.170.72 (0.26-1.95)0.10/0.160.29 (0.05-1.54)0.19/0.171.14 (0.58-2.27)
    H3, T-A0.71/0.780.48 (0.25-0.95)0.71/0.780.45 (0.22-0.93)0.77/0.780.96 (0.41-2.33)0.84/0.782.23 (0.57-8.87)0.74/0.780.69 (0.38-1.24)
IL-13
    J1, G-C0.79/0.712.16 (1.02-4.57)0.73/0.750.95 (0.46-1.95)0.73/0.711.20 (0.53-2.71)0.62/0.561.79 (0.62-5.21)0.74/0.711.40 (0.94-2.10)
    J2, A-C0.09/0.110.88 (0.47-1.64)0.07/0.080.90 (0.28-2.91)0.09/0.062.66 (0.69-10.31)0.18/0.240.45 (0.11-1.78)0.10/0.090.94 (0.55-1.61)
    J3, G-T0.04/0.080.24 (0.05-1.22)0.07/0.080.83 (0.23-2.30)0.07/0.090.53 (0.12-2.29)0.04/0.070.53 (0.04-7.48)0.06/0.080.57 (0.28-1.16)
    J4, A-T0.08/0.100.55 (0.18-1.72)0.12/0.101.36 (0.50-3.74)0.11/0.140.58 (0.17-1.92)0.16/0.131.06 (0.25-4.48)0.11/0.120.84 (0.47-1.51)
  • NOTE: Data are results from population-based case-control studies conducted in Sweden, Southeast England, Denmark, and Finland (2000-2004).

  • * Numbers differ from those in Table 2 because either SNP in haplotype can have missing values.

  • Each haplotype is included in a separate model with the reference category consisting of individuals who did not have that specific haplotype.

  • ORs estimated using two-stage random-effects meta-analysis (28).