Table 1.

Breast cancer risk and polymorphism in GATA3 and its 3′ flanking gene FLJ45983 in two study populations in Norway and Poland

Gene
Norwegian study
Polish study
PheterogeneityPooled estimates
SNPGenotypeCaseControlOR* (95% CI)CaseControlOR* (95% CI)OR* (95% CI)
FLJ45983
    rs1149901 (Ex1-425G>A)GG3856091.009601,1131.001.00
AG2734101.14 (0.86-1.50)7859031.01 (0.88-1.15)1.03 (0.92-1.15)
AA35850.55 (0.29-1.04)1511581.11 (0.88-1.42)0.080.99 (0.80-1.22)
Ptrend0.510.520.81
GATA3
    rs3802604 (IVS4+1468G>A)AA2763871.007778591.001.00
AG3205360.82 (0.61-1.11)8701,0290.93 (0.82-1.06)0.91 (0.81-1.03)
GG851750.78 (0.51-1.17)2422770.96 (0.79-1.17)0.140.90 (0.76-1.06)
Ptrend0.160.460.11
    rs570613 (IVS4+401T>C)TT2563201.007247761.001.00
CT3355680.72 (0.53-0.97)8931,0750.89 (0.78-1.02)0.85 (0.75-0.95)
CC1042110.62 (0.41-0.93)2783250.91 (0.75-1.10)0.82 (0.69-0.96)
Ptrend0.010.190.070.004
    rs422628 (IVS4-27C>T)TT3645761.001,1041,2611.001.00
CT2393961.09 (0.81-1.46)6928090.97 (0.85-1.11)0.98 (0.88-1.10)
CC30770.71 (0.38-1.33)1051091.10 (0.83-1.45)0.97 (0.77-1.24)
P for trend0.720.910.100.74
  • * Adjusted by age, in addition to study in pooled analyses.