Table 4.

Associations of CYP17 htSNPs with prostate cancer in the BPC3

Cases (n = 8,138)*Controls (n = 9,033)*OR (95% CI)P heterogeneity
Block 1
rs7097872
    CC2,5732,8991.00 (ref.)0.59
    CT3,5604,0541.00 (0.93-1.07)
    TT1,1891,4250.94 (0.85-1.03)
P trend = 0.26
rs2486758
    TT4,8245,5581.00 (ref.)0.24
    TC2,6552,8211.07 (1.00-1.14)
    CC4354351.09 (0.95-1.26)
P trend = 0.04
rs743572 (T27C)
    AA2,9013,1971.00 (ref.)0.85
    AG3,8114,2301.00 (0.94-1.07)
    GG1,2361,4070.97 (0.88-1.06)
P trend = 0.57
rs4919687
    GG4,3594,7601.00 (ref.)0.96
    GA3,0803,4320.98 (0.92-1.05)
    AA5476560.90 (0.80-1.02)
P trend = 0.17
rs284849
    GG5,1955,8991.00 (ref.)0.23
    GT2,4852,6221.06 (0.99-1.13)
    TT3513621.05 (0.90-1.22)
P trend = 0.14
Block 2
rs4919682
    CC4,5244,9341.00 (ref.)0.93
    CT2,9683,3320.98 (0.92-1.04)
    TT5206160.91 (0.80-1.03)
P trend = 0.17
rs10883782
    AA5,8566,4511.00 (ref.)0.28
    AG1,9042,1430.98 (0.91-1.05)
    GG1812070.99 (0.80-1.21)
P trend = 0.62
rs619824
    CC2,4462,5941.00 (ref.)0.77
    CA3,7894,2650.96 (0.89-1.03)
    AA1,6481,8780.96 (0.87-1.04)
P trend = 0.27
rs6892
    AA5,3066,0731.00 (ref.)0.28
    AG2,3692,4851.08 (1.00-1.15)
    GG3383291.11 (0.95-1.30)
P trend = 0.03
  • * Numbers do not sum to total due to missing genotype data.

  • The ORs and 95% CIs were estimated using conditional (on matching factors: age, ethnicity, and country within EPIC) logistic regression and adjusted for cohort.

  • P value for heterogeneity in ORs across cohorts.