Table 2.

Associations of CYP17 htSNPs with breast cancer in the BPC3

Cases (n = 5,333)*Controls (n = 7,069)*OR (95% CI)P heterogeneity
Block 1
rs7097872
    CC1,7092,2491.00 (ref.)0.70
    CT2,4153,2191.00 (0.93-1.08)
    TT8421,1011.04 (0.94-1.15)
P trend = 0.53
rs2486758
    TT3,1774,2031.00 (ref.)0.95
    TC1,7162,2840.97 (0.90-1.04)
    CC2513460.96 (0.82-1.12)
P trend = 0.36
rs743572 (T27C)
    AA1,8692,4741.00 (ref.)0.66
    AG2,4453,3380.99 (0.92-1.06)
    GG8331,0701.05 (0.95-1.16)
P trend = 0.49
rs4919687
    GG2,7653,7421.00 (ref.)0.85
    GA1,9922,6441.04 (0.97-1.12)
    AA4094861.17 (1.03-1.34)
P trend = 0.03
rs284849
    GG3,3834,4721.00 (ref.)0.55
    GT1,5942,1420.96 (0.89-1.03)
    TT2082830.96 (0.81-1.14)
P trend = 0.30
Block 2
rs4919682
    CC2,8553,8331.00 (ref.)0.90
    CT1,9122,5281.04 (0.97-1.12)
    TT3794531.16 (1.01-1.33)
P trend = 0.04
rs10883782
    AA3,6504,7221.00 (ref.)0.59
    AG1,3581,9130.95 (0.88-1.03)
    GG1231700.96 (0.77-1.19)
P trend = 0.21
rs619824
    CC1,5262,0821.00 (ref.)0.86
    CA2,5623,4561.01 (0.94-1.10)
    AA1,0701,3591.08 (0.98-1.18)
P trend = 0.14
rs6892
    AA3,4894,6111.00 (ref.)0.33
    AG1,4821,9980.96 (0.89-1.03)
    GG1842381.01 (0.85-1.21)
P trend = 0.46
  • * Numbers do not sum to total due to missing genotype data.

  • The ORs and 95% CIs were estimated using conditional (on matching factors: age, ethnicity, and country within EPIC) logistic regression and adjusted for cohort.

  • P value for heterogeneity in ORs across cohorts.