Table 1.

Associations of CYP17 common haplotypes with breast cancer in the BPC3

Haplotype copiesCases (n = 5,333)*Controls (n = 7,069)*OR (95% CI)P heterogeneity
Block 1
CTAGG02,1192,8061.00 (ref.)0.60
12,4353,2771.00 (0.93-1.07)
27349461.01 (0.91-1.13)
P trend = 0.89
TTGAG02,8473,8321.00 (ref.)0.99
12,0292,7061.03 (0.96-1.11)
24124911.17 (1.02-1.33)
P trend = 0.04
CCAGT03,4554,5711.00 (ref.)0.61
11,6252,1780.96 (0.89-1.03)
22082800.98 (0.83-1.17)
P trend = 0.38
TTGGG04,0415,2851.00 (ref.)0.50
11,1361,6060.93 (0.86-1.01)
21111370.97 (0.78-1.20)
P trend = 0.13
Global test block 1: χ2 = 6.18, 4 df, P = 0.186
Block 2
TAAA02,9433,9581.00 (ref.)0.97
11,9602,6161.04 (0.97-1.11)
23854561.17 (1.02-1.35)
P trend = 0.03
CACA03,2964,4321.00 (ref.)0.25
11,7632,2981.02 (0.95-1.10)
22292991.01 (0.85-1.19)
P trend = 0.61
CACG03,5854,7491.00 (ref.)0.41
11,5212,0390.96 (0.89-1.03)
21832411.00 (0.83-1.19)
P trend = 0.41
CAAA03,4614,5951.00 (ref.)0.59
11,5882,1190.99 (0.92-1.06)
22393140.95 (0.82-1.11)
P trend = 0.54
CGCA03,7864,9041.00 (ref.)0.81
11,3781,9550.94 (0.87-1.02)
21241700.96 (0.77-1.20)
P trend = 0.17
Global test block 2: χ2 = 6.71, 5 df, P = 0.243
  • * Numbers do not sum to total due to missing genotype data.

  • The ORs and 95% CIs were estimated using conditional (on matching factors: age, ethnicity, and country within EPIC) logistic regression and adjusted for cohort.

  • P value for heterogeneity in ORs across cohorts.