Table 6.

Effect of adjusting for IGFBP-3 genotypes on HRs of developing aneuploidy for the quartiles of serum IGFBP-3 among persons with Barrett's esophagus

Biomarker≤Median>MedianPtrend*
IGFBP-31.02.7 (1.2-6.0)0.02
IGFBP-3 (adjusted)1.03.3 (1.5-7.5)<0.01
  • NOTE: HR, adjusted for age categories, gender, smoking status, and quartiles of waist/hip ratios and median splits of IGF-I.

  • * Ptrend values are based on quartile variables.

  • Additional adjustment for three categories of IGFBP-3 −202 A/C genotypes as listed in Table 5.