Table 3.

Haplotype frequencies of NAT1 and NAT2 in patients and controls

HaplotypeHaplotype sequenceAlleleAcetylator phenotypeFrequency in patientsFrequency in controlsPUnivariate OR (95% CI)
NAT1*
    10-0-0-0-0-0-0-0*4Reference0.7430.7590.421.00
    20-0-0-0-0-0-2-2*10Rapid0.1910.1710.261.14 (0.90-1.45)
    30-0-2-0-0-0-0-2*11Rapid0.0240.0140.121.72 (0.85-3.64)
    40-0-0-0-0-0-0-2*3Reference0.0200.0310.140.67 (0.36-1.23)
    50-0-0-0-2-0-2-2*14ASlow0.0120.0200.120.55 (0.24-1.22)
    60-0-0-0-2-0-0-0*14BSlow0.00250.00120.502.01 (0.10-118.9)
    70-0-0-0-0-2-0-0*22Slow0.00100.00100.99NE
    80-0-0-2-0-0-2-2*15Slow0.002000.27NE
    90-0-2-0-0-0-0-00.00285.80E−090.07NE
    100-2-0-0-0-0-0-000.001390.34NE
    110-0-2-0-0-2-0-00.001000.30NE
    120-0-2-0-0-0-2-23.23E−40.0010.61NE
NAT2
    10-0-0-0-0-0-0*4Rapid0.2350.2310.861.00
    20-0-2-2-0-2-0*5BSlow0.4110.4330.330.93 (0.74-1.18)
    30-2-0-0-2-0-0*6ASlow0.2720.2770.810.97 (0.75-1.25)
    40-0-2-2-0-0-0*5ASlow0.0300.0240.421.22 (0.66-2.26)
    50-2-0-0-0-0-2*7BSlow0.0290.0190.151.50 (0.78-2.96)
    60-0-2-0-0-2-0*5CSlow0.0140.0080.251.63 (0.62-4.56)
    70-0-0-0-0-2-0*12ARapid0.00620.00170.122.80 (0.49-28.6)
    80-2-0-0-0-0-0*13Rapid0.00200.00320.610.62 (0.05-5.48)
    90-2-0-0-2-2-0*6CSlow1.73E−80.00150.22NE
    100-0-0-0-2-0-0*6BSlow9.48E−590.00100.30NE
    112-2-0-0-0-0-0*14BSlow9.96E−0400.33NE
NAT1-NAT2
    10-0-0-0-0-0-0-0-0-0*4-*4Reference/rapid0.1250.1220.831.00
    20-0-0-0-0-2-2-0-2-0*4-*5BReference/slow0.3400.3450.830.93 (0.67-1.30)
    30-0-0-0-2-0-0-2-0-0*4-*6AReference/slow0.2120.2450.090.88 (0.69-1.31)
    40-0-2-2-0-0-0-0-0-0*10-*4Rapid/rapid0.0840.0760.501.12 (0.69-1.13)
    50-0-2-2-0-2-2-0-2-0*10-*5BRapid/slow0.0500.0620.230.81 (0.52-1.25)
    60-0-2-2-2-0-0-2-0-0*10-*6ARapid/slow0.0430.0270.061.61 (0.93-2.82)
    70-0-0-0-0-2-2-0-0-0*4-*5AReference/slow0.0300.0240.471.23 (0.67-2.28)
    80-0-0-0-2-0-0-0-0-2*4-*7BReference/slow0.0230.0170.371.35 (0.66-2.79)
    92-0-0-2-2-0-0-2-0-0*11-*6ARapid/slow0.0120.0040.052.94 (0.88-12.6)
    100-2-2-2-0-0-0-0-0-0*14A-*4Slow/rapid0.0110.0150.470.77 (0.31-1.85)
    110-0-0-2-0-0-0-0-0-0*3-*4Reference/rapid0.0100.0180.140.57 (0.23-1.36)
    120-0-0-2-0-2-2-0-2-0*3-*5BReference/slow0.0090.0110.600.78 (0.26-2.24)
    130-0-2-2-0-2-0-0-2-0*10-*5CRapid/slow0.0070.0040.471.71 (0.43-8.05)
    142-0-0-2-0-2-2-0-2-0*11-*5BRapid/slow0.00970.00870.811.10 (0.37-3.32)
    150-0-2-2-2-0-0-0-0-2*10-*7BRapid/slow0.00620.00350.02NE
    160-0-0-0-0-2-0-0-2-0*4-*5CReference/slow0.00710.00240.13NE
    170-0-0-0-0-0-0-0-2-0*4-*12AReference/rapid0.00460.00120.17NE
  • Abbreviation: NE, not estimated because one cell of the contingent table is 0.

  • * NAT1 SNP (5′-3′): C97T, C190T, G445A, C559T, G560A, A752T, T1088A, and C1095A.

  • NAT2 SNP (5′-3′): G191A, C282T, T341C, C481T, G590A, A803G, and G857A.

  • NAT1-NAT2 SNP: G445A, G560A, T1088A, C1095A, C282T, T341C, C481T, G590A, A803G, and G857A.