Table 2.

Association between NAT1 and NAT2 genotypes and risk of pancreatic cancer

GenotypePatients, n (%)Controls, n (%)OR* (95% CI)Acetylator phenotype
NAT1*4/*4291 (55.8)337 (58.4)1.00Reference
NAT1*4/*other13 (2.5)16 (2.8)1.04 (0.45-2.43)
NAT1*10/*other142 (27.2)154 (26.7)1.05 (0.76-1.46)
NAT1*11/*other24 (4.6)18 (3.1)1.19 (0.56-2.54)
NAT1*10/*10 + NAT1*10/*1131 (5.9)23 (4.0)1.97 (1.02-3.82)Rapid
NAT1*4/*321 (4.0)29 (5.0)0.79 (0.39-1.59)Reference
NAT1 other487 (94.0)553 (96.0)1.00
NAT1*10/*10 + NAT1*10/*1131 (6.0)23 (4.0)1.96 (1.03-3.73)Rapid
NAT2*4/*431 (5.9)27 (4.8)1.00Rapid
NAT2*4/*5B111 (21.1)125 (22.2)0.59 (0.30-1.16)Intermediate
NAT2*4/*6A65 (12.4)71 (12.6)0.61 (0.30-1.27)Intermediate
NAT2*4/*59 (1.7)5 (0.9)1.75 (0.36-8.43)Intermediate
Other NAT2 intermediate acetylator genotype10 (1.9)10 (1.8)0.85 (0.27-2.69)Intermediate
NAT2*5B/*6A118 (22.4)124 (22.0)0.72 (0.36-1.42)Slow
NAT2*5B/*5B83 (15.8)104 (18.4)0.67 (0.33-1.34)Slow
NAT2*6A/*6A37 (7.0)45 (8.0)0.64 (0.29-1.40)Slow
NAT2*5A/*5B18 (3.4)14 (2.5)1.07 (0.39-3.00)Slow
NAT2*5B/*7B12 (2.3)11 (1.9)0.77 (0.25-2.39)Slow
NAT2*6A/*7B12 (2.3)9 (1.6)0.80 (0.24-2.67)Slow
NAT2*5/*5 and NAT2*5/*68 (1.7)9 (1.6)0.87 (0.27-2.81)Slow
NAT2*5A/*6A6 (1.1)9 (1.6)0.69 (0.19-2.57)Slow
Other NAT2 slow acetylator genotype5 (0.9)1 (0.2)3.91 (0.39-38.9)Slow
NAT2 other349 (66.4)371 (65.8)1.00
NAT2*6A/any*177 (33.6)193 (34.2)0.97 (0.75-1.26)Slow
  • * OR adjusted for age, sex, pack-year of smoking (categorical), history of diabetes, and NAT2 genotype (slow versus other, for the NAT1 analysis) or NAT1 genotype (rapid versus other, for the NAT2 analysis).

  • NAT1*4/other comprises *4/*14B, *4/*15, *4/*17, *4/*22, *4/*14A, and *10/*14B; *10/other comprises *4/*10, *3/*10, and *10/*14A; *11/other comprises *4/*11A or *3/*11B, *4/*11B, *3/*11A, and *11B/*22.

  • Intermediate comprises *4/*6B, *4/*7B, *5B/*12A, *5B/13, 5B/*14B, *6A/*12A, and *6A/*13; *5 comprises *5A and *5C; *5/*5 and *5/*6 comprise *5B/*5C, *5C/*5C, *5B/*6C, and *5C/*6A; other slow comprises *5A/*7B, *5B/*13, *6A/*6C, and *7B/*7B.