Table 1.

Characteristics of NAT1 and NAT2 SNPs and the linkage disequilibrium coefficients between 10 SNPs

GeneReference SNP IDAmino acid changeMAFP value HWEPairwise linkage disequilibrium coefficients (D′ above diagonal, r2 below diagonal)
NAT1
NAT2
G445AG560AT1088AC1095AC282TT341CC481TG590AA803GG857A
NAT1G445AV149I0.0170.201.000.07
G560AR187Q0.0240.501.001.00−0.60−0.59−0.58
T1088ANone0.1960.370.101.00−0.55−0.27−0.34−0.50−0.23
C1095ANone0.2420.900.050.080.76−0.50−0.23−0.29−0.47−0.18
NAT2C282TNone0.2920.150.030.03−1.00−1.000.99−0.991.00
T341CI114T0.4740.520.0070.020.010.371.00−1.000.99−1.00
C481TNone0.4640.620.0070.030.020.360.96−1.000.95−1.00
G590AR197Q0.2750.270.020.030.900.340.32−0.99
A803GK268R0.4580.640.0070.010.0090.340.920.870.31−1.00
G857AG286E0.0160.150.0050.040.010.010.01
  • NOTE: Blank indicates that SNPs were not in significant linkage disequilibrium.

    Abbreviations: MAF, minor allele frequency; HWE, Hardy-Weinberg equilibrium.