Table 1.

Factors considered when making the choice between tamoxifen and raloxifene for primary prevention in postmenopausal women

FactorDrug favored
Efficacy concern greatestTamoxifen
Safety concern greatestRaloxifene
Dyspareunia/reduced libidoTamoxifen
Benign uterine conditionsRaloxifene
CataractsRaloxifene
Low-activity CYP2D6 allelesRaloxifene
Increased risk for thromboembolismNeither