Table 2.

Predictors of post-LEEP HPV persistence

Persisted after LEEP, n = 231Cleared after LEEP, n = 899OR* (95% CI)
HPV species
    α9/α11100 (17.6)467 (82.4)1.0
    α735 (17.9)160 (82.1)1.0 (0.7-1.6)
    α347 (40.9)68 (59.1)3.3 (2.1-5.0)
    α5/α627 (16.0)142 (84.0)0.8 (0.5-1.3)
    α1/α8/α10/α1322 (26.2)62 (73.8)1.6 (0.9-2.7)
Infection status at LEEP
    Single24 (14.3)144 (85.7)1.0
    Coinfected with other types207 (21.5)755 (78.5)1.6 (1.0-2.6)
    Adjusted for species1.4 (0.9-2.3)
No. CIN2+ blocks cut from the LEEP specimen
    0-189 (16.4)453 (83.6)1.0
    2 or more142 (24.2)446 (75.6)1.7 (1.2-2.3)
    Adjusted for species1.7 (1.2-2.3)
Diagnosis of the LEEP specimen
    <CIN251 (17.0)249 (83.0)1.0
    CIN2+180 (21.7)650 (78.3)1.4 (1.0-2.0)
    Adjusted for species1.5 (1.0-2.3)
  • * The odds of persistence versus clearance are based on generalized estimating equations, as described in Materials and Methods.

  • ORs were adjusted for species because that was the strongest predictor of HPV persistence after LEEP.

  • Used to approximate extent of disease at LEEP.