Table 4.

Stomach cancer risk by MTRR haplotypes and diplotypes, Warsaw, Poland, 1994-1996

Cases, n (%)Controls, n (%)OR (95% CI)*OR (95% CI)
MTRR haplotypes (no. minor alleles)
    0GCGCCAT148 (26.5)231 (29.5)1.001.00
    1GCGCCTT48 (8.6)57 (7.3)1.32 (0.85-2.04)1.21 (0.75-1.96)
    2GCGCTAC114 (20.4)153 (19.5)1.19 (0.86-1.63)1.24 (0.88-1.76)
ACGCCTT93 (16.7)145 (18.5)0.99 (0.71-1.38)1.04 (0.73-1.49)
ACGCTAT70 (12.5)82 (10.5)1.35 (0.92-1.98)1.36 (0.89-2.07)
    3ATGCCTT34 (6.1)45 (5.7)1.18 (0.72-1.93)1.13 (0.66-1.94)
    4ACATCTT24 (4.3)42 (5.4)0.89 (0.52-1.54)0.94 (0.51-1.71)
Others§27 (4.8)29 (3.7)1.47 (0.84-2.59)1.48 (0.78-2.82)
MTRR diplotypes (no. minor alleles in each chromosome)
    0-0GCGCCAT-GCGCCAT18 (6.1)32 (7.8)1.001.00
    0-2GCGCCAT-GCGCTAC37 (12.5)49 (12.0)1.36 (0.66-2.78)1.33 (0.61-2.91)
GCGCCAT-ACGCCTT25 (8.5)45 (11.0)0.99 (0.46-2.11)0.94 (0.42-2.12)
GCGCCAT-ACGCTAT16 (5.4)24 (5.9)1.20 (0.51-2.84)0.97 (0.38-2.48)
    2-2GCGCTAC-ACGCCTT18 (6.1)28 (6.9)1.15 (0.50-2.63)0.93 (0.37-2.31)
Others§181 (61.4)231 (56.5)1.40 (0.76-2.58)1.30 (0.67-2.51)
  • * Adjusted for age and gender.

  • Adjusted for age, gender, education, dietary folate intake, alcohol drinking, cigarette smoking, and total caloric intake.

  • The order of single nucleotide polymorphismss in MTRR are MTRR Ex2−64A>G (A66G), Ex9−85C>T, Ex15−526G>A, Ex14+14C>T, Ex5+123C>T, Ex15−405A>T, and Ex15+572C>T.

  • § Others are consisted of haplotypes/diplotypes with frequencies <5%.