Table 2.

Effect of polymorphisms in MTHFR, MTR, and MTRR on stomach cancer risk, Warsaw, Poland, 1994-1996

Cases, n (%)Controls, n (%)OR (95% CI)*OR (95% CI)
MTHFR Ex5+79C>T rs1801133
    CC146 (49.5)185 (46.4)1.001.00
    CT116 (39.3)178 (44.6)0.82 (0.60-1.13)0.79 (0.56-1.13)
    TT33 (11.2)36 (9.0)1.17 (0.70-1.97)1.13 (0.64-1.99)
    CT/TT149 (50.5)214 (53.6)0.88 (0.65-1.19)0.85 (0.61-1.18)
MTHFR Ex8−62A>C rs1801132
    AA135 (46.4)180 (45.0)1.001.00
    AC125 (43.0)179 (44.8)0.93 (0.68-1.28)1.00 (0.70-1.42)
    CC31 (10.7)41 (10.3)1.02 (0.61-1.71)1.08 (0.62-1.89)
    AC/CC156 (53.6)220 (55.0)0.95 (0.70-1.28)1.01 (0.73-1.41)
MTR Ex26−20A>G rs1805087
    AA182 (62.1)270 (65.4)1.001.00
    AG96 (32.8)123 (29.8)1.17 (0.84-1.62)1.38 (0.96-1.98)
    GG15 (5.1)20 (4.8)1.10 (0.55-2.21)1.18 (0.56-2.48)
    AG/GG111 (37.9)143 (34.6)1.16 (0.85-1.58)1.35 (0.96-1.90)
MTRR Ex2−64A>G rs1801394
    GG106 (35.9)147 (35.6)1.001.00
    AG133 (45.1)188 (45.5)0.98 (0.70-1.37)0.94 (0.65-1.35)
    AA56 (19.0)78 (18.9)0.99 (0.64-1.51)1.10 (0.69-1.76)
    AG/AA189 (64.1)266 (64.4)0.98 (0.72-1.34)0.98 (0.70-1.38)
MTRR Ex5+123C>T rs1532268
    CC118 (39.9)190 (46.3)1.001.00
    CT146 (49.3)176 (42.9)1.35 (0.98-1.85)1.34 (0.94-1.90)
    TT32 (10.8)44 (10.7)1.20 (0.72-1.99)1.18 (0.67-2.06)
    CT/TT178 (60.1)220 (53.7)1.32 (0.97-1.79)1.30 (0.93-1.82)
MTRR Ex9−85C>T rs2287780
    CC260 (87.8)364 (88.8)1.001.00
    CT36 (12.2)45 (11.0)1.12 (0.70-1.79)1.07 (0.64-1.79)
    TT01 (0.2)
    CT/TT36 (12.2)46 (11.2)1.10 (0.69-1.74)1.04 (0.62-1.74)
MTRR Ex14+14C>T rs10380
    CC271 (91.3)361 (88.1)1.001.00
    CT25 (8.4)47 (11.5)0.70 (0.42-1.16)0.68 (0.38-1.21)
    TT1 (0.3)2 (0.5)0.67 (0.06-7.42)0.97 (0.08-11.67)
    CT/TT26 (8.8)49 (12.0)0.70 (0.42-1.15)0.69 (0.39-1.21)
MTRR Ex15-526G>A rs9332
    GG255 (87.6)351 (86.7)1.001.00
    AG36 (12.4)50 (12.4)0.98 (0.62-1.56)0.98 (0.59-1.64)
    AA04 (1.0)
    AG/AA36 (12.4)54 (13.3)0.91 (0.58-1.43)0.93 (0.56-1.54)
MTRR Ex15−405A>T rs8659
    AA107 (36.8)160 (39.3)1.001.00
    AT145 (49.8)181 (44.5)1.20 (0.86-1.67)1.14 (0.79-1.64)
    TT39 (13.4)66 (16.2)0.86 (0.54-1.38)0.93 (0.57-1.54)
    AT/TT184 (63.2)247 (60.7)1.11 (0.81-1.51)1.08 (0.77-1.52)
MTRR Ex15+572C>T rs9282787
    TT182 (62.54)264 (64.39)1.001.00
    TC99 (34.02)129 (31.46)1.13 (0.82-1.56)1.14 (0.80-1.63)
    CC10 (3.4)17 (4.15)0.86 (0.38-1.92)0.98 (0.43-2.24)
    TC/CC109 (37.5)146 (35.6)1.10 (0.80-1.50)1.12 (0.80-1.58)
  • * Adjusted for age and gender.

  • Adjusted for age, gender, education, dietary folate intake, alcohol drinking, cigarette smoking, and total caloric intake.