Effect of polymorphisms in MTHFR, MTR, and MTRR on stomach cancer risk, Warsaw, Poland, 1994-1996
| Cases, n (%) | Controls, n (%) | OR (95% CI)* | OR (95% CI)† | |||||
|---|---|---|---|---|---|---|---|---|
| MTHFR Ex5+79C>T rs1801133 | ||||||||
| CC | 146 (49.5) | 185 (46.4) | 1.00 | 1.00 | ||||
| CT | 116 (39.3) | 178 (44.6) | 0.82 (0.60-1.13) | 0.79 (0.56-1.13) | ||||
| TT | 33 (11.2) | 36 (9.0) | 1.17 (0.70-1.97) | 1.13 (0.64-1.99) | ||||
| CT/TT | 149 (50.5) | 214 (53.6) | 0.88 (0.65-1.19) | 0.85 (0.61-1.18) | ||||
| MTHFR Ex8−62A>C rs1801132 | ||||||||
| AA | 135 (46.4) | 180 (45.0) | 1.00 | 1.00 | ||||
| AC | 125 (43.0) | 179 (44.8) | 0.93 (0.68-1.28) | 1.00 (0.70-1.42) | ||||
| CC | 31 (10.7) | 41 (10.3) | 1.02 (0.61-1.71) | 1.08 (0.62-1.89) | ||||
| AC/CC | 156 (53.6) | 220 (55.0) | 0.95 (0.70-1.28) | 1.01 (0.73-1.41) | ||||
| MTR Ex26−20A>G rs1805087 | ||||||||
| AA | 182 (62.1) | 270 (65.4) | 1.00 | 1.00 | ||||
| AG | 96 (32.8) | 123 (29.8) | 1.17 (0.84-1.62) | 1.38 (0.96-1.98) | ||||
| GG | 15 (5.1) | 20 (4.8) | 1.10 (0.55-2.21) | 1.18 (0.56-2.48) | ||||
| AG/GG | 111 (37.9) | 143 (34.6) | 1.16 (0.85-1.58) | 1.35 (0.96-1.90) | ||||
| MTRR Ex2−64A>G rs1801394 | ||||||||
| GG | 106 (35.9) | 147 (35.6) | 1.00 | 1.00 | ||||
| AG | 133 (45.1) | 188 (45.5) | 0.98 (0.70-1.37) | 0.94 (0.65-1.35) | ||||
| AA | 56 (19.0) | 78 (18.9) | 0.99 (0.64-1.51) | 1.10 (0.69-1.76) | ||||
| AG/AA | 189 (64.1) | 266 (64.4) | 0.98 (0.72-1.34) | 0.98 (0.70-1.38) | ||||
| MTRR Ex5+123C>T rs1532268 | ||||||||
| CC | 118 (39.9) | 190 (46.3) | 1.00 | 1.00 | ||||
| CT | 146 (49.3) | 176 (42.9) | 1.35 (0.98-1.85) | 1.34 (0.94-1.90) | ||||
| TT | 32 (10.8) | 44 (10.7) | 1.20 (0.72-1.99) | 1.18 (0.67-2.06) | ||||
| CT/TT | 178 (60.1) | 220 (53.7) | 1.32 (0.97-1.79) | 1.30 (0.93-1.82) | ||||
| MTRR Ex9−85C>T rs2287780 | ||||||||
| CC | 260 (87.8) | 364 (88.8) | 1.00 | 1.00 | ||||
| CT | 36 (12.2) | 45 (11.0) | 1.12 (0.70-1.79) | 1.07 (0.64-1.79) | ||||
| TT | 0 | 1 (0.2) | — | — | ||||
| CT/TT | 36 (12.2) | 46 (11.2) | 1.10 (0.69-1.74) | 1.04 (0.62-1.74) | ||||
| MTRR Ex14+14C>T rs10380 | ||||||||
| CC | 271 (91.3) | 361 (88.1) | 1.00 | 1.00 | ||||
| CT | 25 (8.4) | 47 (11.5) | 0.70 (0.42-1.16) | 0.68 (0.38-1.21) | ||||
| TT | 1 (0.3) | 2 (0.5) | 0.67 (0.06-7.42) | 0.97 (0.08-11.67) | ||||
| CT/TT | 26 (8.8) | 49 (12.0) | 0.70 (0.42-1.15) | 0.69 (0.39-1.21) | ||||
| MTRR Ex15-526G>A rs9332 | ||||||||
| GG | 255 (87.6) | 351 (86.7) | 1.00 | 1.00 | ||||
| AG | 36 (12.4) | 50 (12.4) | 0.98 (0.62-1.56) | 0.98 (0.59-1.64) | ||||
| AA | 0 | 4 (1.0) | — | — | ||||
| AG/AA | 36 (12.4) | 54 (13.3) | 0.91 (0.58-1.43) | 0.93 (0.56-1.54) | ||||
| MTRR Ex15−405A>T rs8659 | ||||||||
| AA | 107 (36.8) | 160 (39.3) | 1.00 | 1.00 | ||||
| AT | 145 (49.8) | 181 (44.5) | 1.20 (0.86-1.67) | 1.14 (0.79-1.64) | ||||
| TT | 39 (13.4) | 66 (16.2) | 0.86 (0.54-1.38) | 0.93 (0.57-1.54) | ||||
| AT/TT | 184 (63.2) | 247 (60.7) | 1.11 (0.81-1.51) | 1.08 (0.77-1.52) | ||||
| MTRR Ex15+572C>T rs9282787 | ||||||||
| TT | 182 (62.54) | 264 (64.39) | 1.00 | 1.00 | ||||
| TC | 99 (34.02) | 129 (31.46) | 1.13 (0.82-1.56) | 1.14 (0.80-1.63) | ||||
| CC | 10 (3.4) | 17 (4.15) | 0.86 (0.38-1.92) | 0.98 (0.43-2.24) | ||||
| TC/CC | 109 (37.5) | 146 (35.6) | 1.10 (0.80-1.50) | 1.12 (0.80-1.58) | ||||