Table 3.

ORs and 95% CIs for vitamin D receptor (VDR), CYP27B1 (1-α-hydroxylase), and CYP24A1 (24-hydroxylase) tag SNPs and risk of prostate cancer

Tag SNP rs # (location)GenotypeCases* (n)Controls* (n)OR (95% CI)Ptrend
VDR
    Block A
        rs2544038 (23,295 bp 3′ of STP)TT1971921.00 (reference)
CT2822461.13 (0.87-1.47)
CC1021050.99 (0.70-1.39)0.88
CT+CC1.09 (0.85-1.39)
    Block B
        rs739837 (Ex11+568)TT1501491.00 (reference)
GT2892821.02 (0.77-1.34)
GG1411211.18 (0.84-1.64)0.35
GT+GG1.06 (0.82-1.39)
        rs731236, TaqI (Ex11+32)TT2381881.00 (reference)
CT2542720.73 (0.56-0.95)
CC94850.91 (0.64-1.29)0.22
CT+CC0.77 (0.60-0.99)
        rs1544410, BsmI (IVS10+283)GG2211771.00 (reference)
AG2792800.77 (0.59-0.99)
AA90840.87 (0.61-1.25)0.21
AG+AA0.79 (0.62-1.01)
        rs2239182 (IVS5+3419)GG1491381.00 (reference)
AG2752810.89 (0.67-1.18)
AA1461321.05 (0.76-1.47)0.77
AG+AA0.94 (0.72-1.23)
        rs2107301 (IVS5+3260)CC3003131.00 (reference)
CT2172021.11 (0.87-1.43)
TT60272.47 (1.52-4.00)0.002
CT+TT1.27 (1.00-1.61)
        rs2239181 (IVS5+2881)TT4474251.00 (reference)
GT1161091.00 (0.74-1.34)
GG541.35 (0.36-5.11)0.88
GT+GG1.01 (0.75-1.35)
        rs2238139 (IVS5+2550)TT3583191.00 (reference)
CT1752100.75 (0.58-0.96)
CC26151.61 (0.83-3.10)0.35
CT+CC0.80 (0.63-1.03)
        rs3782905 (IVS4+6584)CC2782571.00 (reference)
CG2482310.99 (0.77-1.27)
GG58590.93 (0.62-1.39)0.75
CG+GG0.98 (0.77-1.23)
        rs7974708 (IVS4+2586)TT2712361.00 (reference)
CT2352430.86 (0.67-1.11)
CC74670.99 (0.68-1.45)0.60
CT+CC0.89 (0.70-1.13)
        rs11168275 (IVS4+476)AA3393101.00 (reference)
AG2202130.94 (0.74-1.21)
GG23280.75 (0.42-1.33)0.36
AG+GG0.92 (0.73-1.17)
    No block
        rs10735810, FokI (Ex4+4)GG2222221.00 (reference)
AG2612451.09 (0.84-1.41)
AA100851.22 (0.87-1.73)0.25
AG+AA1.12 (0.88-1.43)
    Block C
        rs2408876 (IVS3−667)TT2002031.00 (reference)
CT2872451.19 (0.92-1.54)
CC91930.99 (0.70-1.41)0.72
CT+CC1.14 (0.89-1.45)
        rs2238135 (IVS2−1633)GG3103161.00 (reference)
CG2391961.22 (0.95-1.56)
CC48251.95 (1.17-3.26)0.007
CG+CC1.30 (1.03-1.65)
        rs10875694 (IVS2−5103)AA3843761.00 (reference)
AT1801551.14 (0.88-1.49)
TT20121.75 (0.84-3.63)0.12
AT+TT1.18 (0.92-1.52)
        rs11168287 (IVS2−8206)TT1491301.00 (reference)
CT2762930.85 (0.64-1.13)
CC1541211.15 (0.82-1.61)0.42
CT+CC0.94 (0.71-1.23)
        rs7299460 (IVS1+2470)CC2732501.00 (reference)
CT2402350.90 (0.70-1.16)
TT53570.72 (0.46-1.11)0.13
CT+TT0.87 (0.68-1.10)
        rs11168314 (−27390)CC3563361.00 (reference)
CT1921791.00 (0.78-1.29)
TT23250.86 (0.48-1.56)0.77
CT+TT0.98 (0.77-1.26)
        rs4073729 (−20950)CC4023791.00 (reference)
CT1681471.04 (0.80-1.35)
TT1681.95 (0.82-4.66)0.33
CT+TT1.09 (0.84-1.40)
        rs4760674 (−1005)CC2241981.00 (reference)
AC2822590.99 (0.76-1.28)
AA78820.88 (0.61-1.26)0.55
AC+AA0.96 (0.75-1.23)
        rs6823 (Ex7−250)CC1961641.00 (reference)
CG2832620.91 (0.70-1.19)
GG1121160.83 (0.59-1.15)0.26
CG+GG0.89 (0.69-1.14)
        rs2071358 (740 bp 3′ of STP)CC3823621.00 (reference)
AC1761611.04 (0.80-1.34)
AA13140.82 (0.38-1.78)0.98
AC+AA1.02 (0.79-1.31)
CYP27B1
    Block A
        rs3782130CC2602601.00 (reference)
CG2512291.14 (0.89-1.46)
GG75611.30 (0.89-1.90)0.14
CG+GG1.17 (0.92-1.48)
    No block
        rs4646537 (IVS8+113)AA5464971.00 (reference)
AC38430.76 (0.48-1.21)
CC02N/A
AC+CC0.72 (0.46-1.14)
CYP24A1
    Block A
        rs927650 (IVS11+967)CC1651431.00 (reference)
CT2732670.91 (0.68-1.21)
TT1291280.91 (0.65-1.28)0.58
CT+TT0.91 (0.70-1.19)
        rs912505 (IVS7−1179)AA3503541.00 (reference)
AG2161691.28 (1.00-1.65)
GG23270.81 (0.45-1.45)0.33
AG+GG1.22 (0.96-1.55)
    Block B
        rs6127118 (IVS7+204)GG3253311.00 (reference)
AG2291961.20 (0.93-1.53)
AA00N/A
        rs6068816 (Ex6+12)CC4544431.00 (reference)
CT118931.26 (0.93-1.71)
TT1181.38 (0.55-3.46)0.11
CT+TT1.27 (0.95-1.71)
        rs2762939 (IVS5−149)GG3193001.00 (reference)
CG2121961.01 (0.79-1.30)
CC37430.69 (0.42-1.12)0.34
CG+CC0.95 (0.75-1.21)
    Block C
        rs2244719 (IVS4−486)TT1861471.00 (reference)
CT2742520.88 (0.67-1.16)
CC1361410.79 (0.57-1.09)0.15
CT+CC0.85 (0.65-1.10)
        rs3787557 (IVS4−763)TT4274181.00 (reference)
CT1541201.29 (0.98-1.70)
CC5100.51 (0.17-1.51)0.29
CT+CC1.23 (0.94-1.61)
    No block
        rs2181874 (IVS4+1653)GG3393141.00 (reference)
AG1992010.91 (0.71-1.17)
AA36360.87 (0.53-1.42)0.39
AG+AA0.90 (0.71-1.14)
    Block D
        rs4809960 (IVS4+58)TT3293231.00 (reference)
CT2301841.26 (0.98-1.62)
CC27370.76 (0.45-1.28)0.57
CT+CC1.18 (0.93-1.50)
        rs2296241 (Ex4+9)AA1521571.00 (reference)
AG2852751.04 (0.79-1.38)
GG1341071.28 (0.91-1.79)0.17
AG+GG1.11 (0.85-1.44)
    No block
        rs2245153 (IVS3−179)TT3643641.00 (reference)
CT2041651.23 (0.95-1.58)
CC15250.59 (0.30-1.15)0.73
CT+CC1.14 (0.90-1.46)
        rs2585428 (IVS3−670)GG1861611.00 (reference)
AG2832580.95 (0.72-1.25)
AA1141250.78 (0.56-1.08)0.15
AG+AA0.89 (0.69-1.15)
        rs13038432 (IVS3+814)AA4934661.00 (reference)
AG76621.18 (0.82-1.69)
GG10110.90 (0.38-2.14)0.60
AG+GG1.14 (0.81-1.59)
        rs6022999 (IVS3+103)AA3242981.00 (reference)
AG2252080.97 (0.76-1.24)
GG37420.67 (0.41-1.10)0.23
AG+GG0.92 (0.73-1.17)
  • * Numbers of cases or controls do not equal total because of missing genotypes.

  • Unconditional logistic regression model adjusted for age and ethnicity.

  • Analysis for linear trend according to the number of variant alleles present.