Table 2.

ORs and 95% CIs for common tag SNP haplotypes in vitamin D receptor (VDR), CYP24A1 (24-hydroxylase), and risk of prostate cancer

Tag SNP haplotypesHaplotype distribution
OR (95% CI)*PGlobal P
CasesControls
VDR
    Block B,§
        T_C_A_G_C_T_T_G_C_A0.200.221.00 (reference)0.17
        G_T_G_A_C_T_C_C_T_A0.110.111.01 (0.74-1.39)0.95
        G_T_G_A_C_T_T_C_T_A0.060.061.07 (0.70-1.62)0.76
        G_T_G_A_T_T_T_C_T_A0.060.061.28 (0.83-1.97)0.26
        G_T_G_A_T_T_T_C_T_G0.090.071.35 (0.95-1.93)0.10
        T_C_A_G_C_T_T_C_T_A0.090.091.02 (0.72-1.43)0.93
        Rare0.400.40
    Block C,**
        T_G_A_T_C_C_C_A_G_C0.140.141.00 (reference)0.58
        C_C_T_C_C_C_C_C_C_C0.090.081.10 (0.76-1.58)0.62
        C_G_A_T_T_C_C_A_G_C0.050.080.63 (0.41-0.96)0.03
        T_C_A_C_C_C_C_C_C_C0.060.051.19 (0.76-1.84)0.44
        T_G_A_C_T_T_T_C_C_C0.050.061.03 (0.64-1.65)0.91
        Rare0.660.66
CYP24A1
    Block A††
        T_A0.470.491.00 (reference)0.57
        C_A0.310.311.01 (0.83-1.22)0.94
        C_G0.220.201.11 (0.89-1.38)0.35
    Block B‡‡
        G_C_G0.540.541.00 (reference)0.55
        A_C_G0.090.091.06 (0.75-1.49)0.75
        A_T_G0.110.091.30 (0.96-1.77)0.09
        G_C_C0.240.250.94 (0.77-1.16)0.57
        Rare0.020.03
    Block C§§
        C_T0.460.491.00 (reference)0.30
        T_C0.140.131.19 (0.99-1.43)0.19
        T_T0.400.381.14 (0.96-1.36)0.29
    Block D∥∥
        T_G0.480.451.00 (reference)0.25
        C_A0.240.240.98 (0.80-1.21)0.88
        T_A0.270.310.82 (0.67-1.01)0.06
        Rare0.010.01
  • * Unconditional logistic regression model adjusted for age and ethnicity.

  • Global test for association using likelihood ratio statistic.

  • Loci of tag SNPs are written 3′ to 5′ and include the following: rs739837, rs731236, rs1544410, rs2239182, rs2107301, rs2239181, rs2238139, rs3782905, rs7974708, and rs11168275.

  • § Men missing 17 or more alleles were excluded (cases = 26, controls = 4).

  • Frequency of any of the other haplotypes was <5%.

  • Loci of tag SNPs are written 3′ to 5′ and include the following: rs2408876, rs2238135, rs10875694, rs11168287, rs7299460, rs11168314, rs4073729, rs4760674, rs6823, and rs2071358.

  • ** Men missing 17 or more alleles were excluded (cases = 18, controls = 8).

  • †† Loci of tag SNPs are written 3′ to 5′ and include the following: rs927650 and rs912505.

  • ‡‡ Loci of tag SNPs are written 3′ to 5′ and include the following: rs6127118, rs6068816, and rs2762939.

  • §§ Loci of tag SNPs are written 3′ to 5′ and include the following: rs2244719 and rs3787557.

  • ∥∥ Loci of tag SNPs are written 3′ to 5′ and include the following: rs4809960 and rs2296241.